Optogenetics Equipment and Custom Solutions

Overview
Custom Cannula
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OG Selection Guide

Optogenetics Selection Guide
Optogenetics Overview
Fiber Optic Cannulae
Stereotaxic Cannula Holders and Adapter Arms
Cannula Implant Guides
Rotary Joint Patch Cables
Lightweight Patch Cables
1x1 Rotary Joint
Interconnect and Mating Sleeves
Multimode Fiber Couplers
1x2 Rotary Joint Splitter
LED Light Sources
Laser Light Source
Customizable Optogenetics Kits

Thorlabs Optogenetics Equipment

Thorlabs' Optogenetics Equipment is used Extensively in Leading Optogenetics Labs
Custom Optogenetics Equipment Built to Order
Complete System Including Fiber Optic Cannulae, Fiber Patch Cables, and Light Sources
Stock Components (Same Day Shipping)

Fiber Optic Cannulae
Stereotaxic Cannula Holders and Adapter Arms
Cannula Implant Guides
Fiber Optic Patch Cables
Rotary Joint Fiber Optic Patch Cables
Lightweight Patch Cables
Rotary Joint
Fiber Optic Interconnect and Mating Sleeves
Fiber Optic Couplers/Splitters
Rotary Joint Splitters
LED and Laser Light Sources
Complete Optogenetics Kits

Next-Day Availability for Custom Patch Cable Orders Placed Before 2 PM EST

Thorlabs offers a full line of optogenetics equipment for in vivo stimulation, including implantable fiber optic cannulae, fiber optic patch cables and rotary joints, and LED and laser light sources. We are also well equipped to provide custom optogenetics packages including fiber-coupled light sources and custom-made cannulae. Please contact Tech Support for individual assistance regarding optogenetics equipment selection.

Interactive Optogenetics System Schematic

Click on the components or labels for more details about our optogenetics line of products. Contact Tech Support for more information about our expanding line of optogenetics products.

Optogenetics System Schematic

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Ferrule Patch Cables are ideal for connection to our Implantable Fiber Optic Cannulae.

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Thorlabs' Dual-Core Fiber Optic Patch Cable and Dual-Core Implantable Cannula enable light at different wavelengths to be inserted in close proximity.

Fiber Optic Cannulae

Low-Profile Implantable Fiber Optic Cannulae
Ø1.25 mm and Ø2.5 mm Ceramic and Stainless Steel Ferrules Available
Ø200 µm, Ø300 µm, and Ø400 µm Multimode Optical Fiber Available
Precision-Cleaved or Scissor-Cut Fiber End
Custom Cannula Also Available (see the Custom Cannula Tab)

Thorlabs offers stock and custom fiber optic cannulae, which can be surgically mounted to the skull of the specimen using stereotactic guidance. Custom cannulae are available with a stainless steel or ceramic ferrules as well as an array of different fiber types, lengths, and end terminations. See the Custom Cannula tab above for details.

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Fiber Optic Cannula are available in various fiber lengths and ferrule sizes.

Fiber Optic Cannula Selection Guide
Ferrule Size	Single Core			Dual Core	Empty Ferrule
Ø1.25 mm	Stainless Steel	Ceramic	Uncleaved Fiber End	-	Ceramic
Ø2.5 mm	Stainless Steel	Ceramic	Uncleaved Fiber End	Stainless Steel	Ceramic

Two Methods of Use

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The cannula holder can be attached directly to an adapter arm by using the left-handed 8-32 tap at the end of the cannula holder.

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Alternatively, the XC-CLAMP can be used to allow for coarse height adjustment between the cannula holder and the XC7 adapter arm.

Stereotaxic Cannula Holders and Adapter Arms

Cannula Holders Secure Ø1.25 mm or Ø2.5 mm Fiber Optic Cannulae During Implantation
Requires Less Force to Use than Competing Solutions, Reducing Stress on the Specimen
Ø5 mm and Ø7.9 mm Adapter Arms Provide Compatibility with Most Stereotaxic Equipment
Adapter Clamp for Coarse Height Adjustment of Cannula Holder
Stainless Steel Construction for Easy Sterilization

Thorlabs' Cannula Holders and Adapters are designed to securely hold a fiber optic cannula during implantation using a stereotaxic apparatus. For easy sterilization and repeated use, these holders and adapters are manufactured using stainless steel. The cannula holders feature an easy-to-use chuck that minimizes the stress on the specimen during implantation and when releasing the cannulae. For compatibility with most standard stereotaxic equipment, the cannula holders contain 8-32 threads that can accept our Ø5 mm and Ø7.9 mm adapter arms. Additionally, the cannula holders and adapter arms can also be used with the adapter clamp sold below, which provides coarse height adjustment of a cannula holder and Ø7.9 mm adapter arm via two 1/4"-20 thumbscrews.

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Implant Guide Assembly

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Weep holes for epoxy to escape

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Mounting Surface of OGF Cannula Impant Guide

Cannula Implant Guides

Improves Adhesion and Stability During Implantation
Compatible with Ø1.25 mm and Ø2.5 mm Fiber Optic Cannulae with ≥5 mm Length
Ø3.8 mm (OGL) or Ø5.1 mm (OGF) Mounting Surface with Grooved Ring for Dental Cement
Lightweight Surgical Titanium Construction (≤0.11 g)
Weep Holes for Glue and Epoxy to Secure a Cannula
Compatible with Stereotaxic Cannula Holders

These Cannula Implant Guides are designed to provide guidance and stability for a fiber optic cannula during an implantation procedure. The bottom surface of each implant guide features a roughened surface and circular groove (see image to the right) that increase the surface area available to dental cement and improves adhesion to the specimen. A 1.6 mm long protrusion on the implant guide helps stabilize the guide when implanted. Each implant is constructed using lightweight surgical titanium (≤0.11 g) which can be sterilized prior to use.

For best results when implanting a cannula, the OGL and OGF should be used with a cannula holder and stereotaxic guidance equipment. To affix the cannula within the implant guide, first insert the cannula into the receptacle of the implant guide. Then, add a small amount of cement or epoxy to the cannula via the two Ø0.8 mm weep holes (see image above). Finally, attach the cannula ferrule to an XCL (Ø1.25 mm ferrule) or XCF (Ø2.5 mm ferrule) cannula holder (see image above).

The OGL implant guide is compatible with our standard Ø1.25 mm cannulae (ceramic and stainless steel) and the OGF implant guide is compatible with our standard Ø2.5 mm cannulae (ceramic and stainless steel). When assembled, the length of the protruding fiber is reduced by 1 mm (Item # OGL) or 2 mm (Item # OGF); therefore, these implant guides cannot be used with our 2 mm long cannulae. Additionally, due to the fiber separation distance, the implant guides cannot be used with our dual-core cannulae.

Optogenetics Patch Cables Selection Guide
Ferrule Size	Single Core		Dual Core
Ø1.25 mm	FC/PC	SMA	-
Ø2.5 mm	FC/PC	SMA	FC/PC and SMA

Fiber Patch Cables

Fiber Optic Rotary Joint Patch Cables

Articulated Rotary Joint Prevents Fiber Damage Caused by Moving Specimen
Integrated Ø200 µm or Ø400 µm Core Fiber Patch Cables
Stainless Steel Armor on Specimen Side Available for Ø200 µm Patch Cables with Ø2.5 mm Ferrule Ends
Single Cable Connects Cannula and Light Source in Optogenetics Experiments
Extremely Smooth Rotation
SM05-Threaded Housing for Secure Mounting

Our articulated fiber optic patch cables feature a rotary joint interface that allows the cable to freely rotate, reducing damage in optogenetics experiments. They provide a complete solution for connecting the light source to an implanted fiber optic cannula and are compatible with all Thorlabs light sources and optogenetics equipment.

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RJPFF2 Rotary Joint Patch Cable

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Rotary Joint Detail

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Ø1.25 mm Ferrule Optogenetics Patch Cable

Standard Lightweight Fiber Optic Patch Cables

Large Selection of Multimode Fiber Patch Cables Ideal for Optogenetics
Cables are Compatible with Ø1.25 mm and Ø2.5 mm Ferrule Cannulae
Cables are Lightweight and Flexible for Specimen Mobility

Our optogenetics patch cables can be used to connect a light source to a fiber optic implantable cannulae. We offer small diameter fiber that minimizes tissue damage, as well as extra lightweight cables for Ø1.25 mm cannulae.

Specialty Fiber Patch Cables

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Custom 7 to 1 Fan Out Cable

Extensive Custom Cable Capabilities and In-House Fiber Manufacturing
Examples of Custom Optogenetics Cables Include:

7 to 1 Fan-Out Cable for Incorporating Multiple Light Sources into a Single Probe
Stainless Steel Armored Cable for Protection from Specimen Damage

See the Custom Cables Tab Above, or Contact Tech Support to Order a Custom Cable

We can custom fabricate cables, including armored cable for protection from specimen damage and fan out cables for incorporating multiple light sources into one fiber optic implant. See the Custom Cables tab above for details.

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The RJ1 rotary joint has terminated ends and accepts a wide variety of FC/PC patch cables.

1x1 Rotary Joint for FC/PC Multimode Patch Cables

Rotary Joint Protects Against Fiber Damage Caused by Moving Specimen
Consistent Performance Over 400 - 700 nm Wavelength Range
Low Transmission Variation During Rotation
Recommended for ≥Ø200 µm Core, 0.22 to 0.50 NA Patch Cables
Tested and Designed for Use with a Multimode Laser or Fiber-Coupled LED

Thorlabs' RJ1 1x1 Rotary Joint for FC/PC Multimode Patch Cables is a single input and output rotary joint with low rotational variation. Designed for use in optogenetics, the rotary interface allows patch cables to rotate freely when attached to a moving specimen, reducing the risk of both fiber damage and intensity fluctuations. The input and output patch cables are not permanently attached to the rotary joint, and, as a result, can be selected with a specific core size, NA, and jacketing type to optomize an experiment. This also allows cables to be easily replaced if fibers are damaged. For best performance, we recommend using multimode fibers with a core diameter ≥Ø200 µm and NA between 0.22 to 0.50. Thorlabs can provide custom rotary joints that are aligned and optimized using other patch cables or light sources; please contact Tech Support with inquiries.

The ADAF2 Interconnect enables simple mating and disconnections for our Ø2.5 mm ferrule optogenetics components.

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The ADAL1 Mating Sleeve is designed to mate Ø1.25 mm ferrule cannulae and patch cables.

Interconnect and Mating Sleeves

Ceramic Mating Sleeves for Ø1.25 mm or Ø2.5 mm Bare Ferrules (Sold Individually or in Packs of 5)
Quick-Release Interconnect for Mating Ø1.25 mm or Ø2.5 mm Ferrule Patch Cables to Cannulae
Compatible with Stainless Steel and Ceramic (Zirconia) Ferrules

Thorlabs offers interconnects and mating sleeves for making connections between our line of optogenetics patch cables and fiber optic cannulae. These ferrule mating components provide low-loss coupling and are compatible with both stainless steel and ceramic (zirconia) ferrules. Interconnects are designed to facilitate easy connections and disconnections from an implanted cannula, requiring >80% less force to disconnect compared to mating sleeves. On the other hand, mating sleeves are preferred for very lightweight (~0.18 g), low-profile connections between a patch cable and cannula.

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2x2 Multimode Fiber Coupler

Fiber Optic Couplers / Splitters

Thorlabs multimode fiber couplers are optimized for Optogenetics applications such as bilateral stimulation, where one light source is used to illuminate two fiber optic implants placed close together in the specimen. Couplers are available from stock with 1x2 and 2x2 configurations. Our couplers have SMA905 or FC/PC connectors on the input legs for compatibility with fiber-coupled LED and laser light sources. They are available with Ø2.5 mm ferrule ends on the output legs for direct connection to a fiber optic cannula, or with standard SMA905 or FC/PC connectors for use with other patch cables, such as our rotary joint cables featured above.

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Schematic illustrates the input and output ports of the RJ2 1x2 rotary joint.

Rotary Joint Splitter

Rotary Joint Protects Against Fiber Damage Caused by Moving Specimen
400 – 700 nm Wavelength Range
50:50 Intensity Split of Input Light
Low Transmission Variation During Rotation
Recommended for ≥Ø200 µm Core, 0.22 to 0.50 NA Patch Cables
Tested and Designed for Use with a Multimode Laser or Fiber-Coupled LED

Thorlabs' RJ2 1x2 Rotary Joint Splitter is designed for optogenetics applications and is used to split light from a single input evenly between two outputs. The rotary joint interface allows connected patch cables to freely rotate, reducing the risk of fiber damage caused by a moving specimen. The rotary joint accepts any FC/PC-terminated patch cable, such as our optogenetics, multimode, and hybrid patch cables. For best performance, we recommend using multimode patch cables with a TECS-clad fiber, core diameter ≥Ø200 µm, and NA between 0.22 to 0.50. Thorlabs can provide custom rotary joint splitters that are aligned and optimized using other patch cables or light sources; please contact Tech Support with inquiries.

Light Sources

Thorlabs offers a variety of fiber-coupled light sources that can be used for in vivo stimulation. Our Fiber-Coupled LEDs offer a durable, economic solution with a variety of wavelength choices. Our Fiber-Coupled Lasers, Pigtailed Laser Diodes, and Benchtop Laser Diodes provide higher power at the cannula tip, and our Multichannel Light Sources offers a variety of wavelengths in a compact unit.

Connectorization Supplies
Bare Optical Fiber
Fiber Connectors
Empty Cannula Ferrules
Furcation Tubing
Connectorization Tools
Connector Polishing Supplies
Connectorization Tool Kit
Step-by-Step Connectorization Manual

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Multimode Optical Fiber

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SMA Connector Components

Cable and Cannula Building Supplies

Bare Optical Fiber, Ferrules, Tubing, Connectors, and Tools
Build Custom Cannulae and Fiber Optic Patch Cables
Connectorization Kit Provides all Necessary Tools
Complete Connectorization Instructions Available for Download

Thorlabs stocks individual components for building custom fiber optic cannulae and patch cables, including optical fiber, ferrules, connectors, tubing, and connectorization tools. Our FN96A connectorization manual, which is free to download, gives clear instructions on how to add connectors to optical fiber.

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Example Kit with Ø400 µm Core Fiber, Ø2.5 mm Ferrules, and Rotary Joint Patch Cable

Customizable Optogenetics Kits

Complete Fiber Optics Setup
Substitute or Remove Items for Tailored Use
LED, Patch Cable, Cannulae, and Accessories
Ferrule Options:

Ø1.25 mm Ferrules (Ø200 or Ø400 µm Core)
Ø2.5 mm Ferrules (Ø200 or Ø400 µm Core)

Patch Cable Options
- Standard Lightweight Patch Cable, 1 m Long
- Patch Cable with Integrated Rotary Joint, 3 m Long
Multiple Lengths of Cleaved Cannulae
Certain Kits Include Uncleaved Cannulae and Cleaving Tools
Cannula Holders for Stereotaxic Implantation
Cleaning Supplies

Thorlabs' optogenetics equipment is available in complete, ready-to-use kits. These optogenetics kits are comprised of essential supplies to establish and maintain optogenetics experiments; kit contents may be substituted or removed to suit individual needs. Each kit includes a 470 nm Fiber-Coupled LED with driver, lightweight patch cables, interconnect and mating sleeves, cannulae, and fiber handling and maintenance tools. We offer kits with Ø200 µm or Ø400 µm fiber components and Ø1.25 mm or Ø2.5 mm ferrules.

For information concerning custom orders, pricing, and availability, please contact Tech Support .

Custom Fiber Optic Cannula

Thorlabs offers custom cannulae with the following options. Place a quote request through the following form to receive a quote for your custom cannula order.

Custom Cannula Worksheet:

Fiber Type:
Ferrule Size:	Ø2.5 mm (FC) \| Ø1.25 mm (LC) (Custom length ferrules are also available. Contact Tech Support for details.)
Ferrule Material:	Stainless Steel \| Ceramic (Zirconia)
Fiber End:	Flat Cleave (tolerance of ±0.5 mm) \| Scissor Cut
*Fiber Length (mm):**	Length is specified as in the diagram above, with tolerance as noted.
*Quantity:**
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Customer Information:

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Quick Links
Single-Site Stimulation
One Light Source to One Cannula Implant
Bilateral Stimulation
One Light Source to Two Cannula Implants Using Rotary Joint Splitter
One or Two Light Sources to Two Cannula Implants
Two Light Sources into One Dual-Core Cannula Implant
Illumination
Fiber-Coupled LEDs and Drivers

Optogenetics Selection Guide

Thorlabs offers a wide range of optogenetics components; the compatibility of these products in select standard configurations is discussed in detail here. Please contact Technical Support for assistance with items outside the scope of this guide, including custom fiber components for optogenetics.

Single-Site Stimulation

One Light Source to One Cannula Implant

The most straightforward method for in vivo light stimulation of a specimen is to use a single fiber optic with a single LED light source. The single wavelength LED is powered by an LED driver, and then the illumination output is fiber-coupled into a patch cable, which connects to the implanted cannula. See the graphics and expandable compatibility tables below for the necessary patch cables and cannulae to create this setup. To choose the appropriate LED and driver, see below or the full web presentation.

Click on Each Component for More Information

Click for Details

Click to See Ø1.25 mm (LC) Ferrule Compatible Patch Cables, Cannulae, and Interconnects

Component Selection Table (Click Links for Item Description Popup)
Fiber Type		FG105LCA	FG200UCC	FT200EMT	FP200URT	FT400EMT	FP400URT
Fiber Type Specs	Core Diameter	105 µm	200 µm			400 µm
	Wavelength Range	400 - 2400 nm	250 - 1200 nm	400 - 2200 nm	300 - 1200 nm	400 - 2200 nm	300 - 1200 nm
	NA	0.22	0.22	0.39	0.50	0.39	0.50
Patch Cables^b	Standard FC/PC Input	M61L01	M86L005 M86L01	M83L01 MR83L01	M73L01	M99L01	M127L01
	Standard SMA905 Input	M63L01	M87L005 M87L01	M89L01 MR89L01	M95L01	M98L01	M125L01
	Rotary Joint FC/PC Input	-	-	RJPFL2	-	RJPFL4	-
	Rotary Joint SMA905 Input	-	-	RJPSL2	-	RJPSL4	-
Compatible Mating Sleeve/Interconnect		ADAL1, ADAL3, or ADAL4-5
Fiber Optic Cannulae^c	Ceramic 6.4 mm Long Ferrule	CFMLC21L02 CFMLC21L05 CFMLC21L10 CFMLC21L20 CFMLC21U-20	CFMLC22L02 CFMLC22L05 CFMLC22L10 CFMLC22L20 CFMLC22U-20	CFMLC12L02 CFMLC12L05 CFMLC12L10 CFMLC12L20 CFMLC12U-20	CFMLC52L02 CFMLC52L05 CFMLC52L10 CFMLC52L20 CFMLC52U-20	CFMLC14L02 CFMLC14L05 CFMLC14L10 CFMLC14L20 CFMLC14U-20	CFMLC15L02 CFMLC15L05 CFMLC15L10 CFMLC15L20
	Diffuser Tip (Ceramic 6.4 mm Long Ferrule)	-	-	CFDSB02 CFDSB05 CFDSB10 CFDSB20	-	-	-
	Ceramic 10.5 mm Long Ferrule	-	CFMXA02 CFMXA05 CFMXA10 CFMXA20	CFMXB02 CFMXB05 CFMXB10 CFMXB20	CFMXC02 CFMXC05 CFMXC10 CFMXC20	-	CFMXD02 CFMXD05 CFMXD10 CFMXD20
	Stainless Steel 6.4 mm Long Ferrule	CFML21L02 CFML21L05 CFML21L10 CFML21L20 CFML21U-20	CFML22L02 CFML22L05 CFML22L10 CFML22L20 CFML22U-20	CFML12L02 CFML12L05 CFML12L10 CFML12L20 CFML12U-20	CFML52L02 CFML52L05 CFML52L10 CFML52L20 CFML52U-20	CFML14L02 CFML14L05 CFML14L10 CFML14L20 CFML14U-20	CFML15L02 CFML15L05 CFML15L10 CFML15L20
Items are compatible with each other when they are comprised of the same fiber type and listed in the same column. Patch cables for single source to single implant applications are highlighted in green above. Choose a patch cable with an input that matches your light source. Available cannulae are highlighted in orange of the table above. Cannulae within the same column are interchangeable.

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Click to See Ø2.5 mm (FC) Ferrule Compatible Patch Cables, Cannulae, and Interconnects

Component Selection Table (Click Links for Item Description Popup)
Fiber Type		FG200UCC	FT200EMT	FP200URT	FT300EMT	FT400EMT	FP400URT
Fiber Type Specs	Core Diameter	200 µm			300 µm	400 µm
	Wavelength Range	250 - 1200 nm	400 - 2200 nm	300 - 1200 nm	400 - 2200 nm	400 - 2200 nm	300 - 1200 nm
	NA	0.22	0.39	0.50	0.39	0.39	0.50
Patch Cables^b	Standard FC/PC Input	M80L005 M80L01	M81L005 M81L01 MR81L01	M104L01	M56L005 M56L01	M82L005 M82L01	M128L01
	Standard SMA905 Input	M84L005 M84L01	M77L005 M77L01 MR77L01	M106L01	M58L005 M58L01	M79L005 M79L01	M126L01
	Rotary Joint FC/PC Input	-	RJAFF2 RJPFF2	-	-	RJPFF4	-
	Rotary Joint SMA905 Input	-	RJASF2 RJPSF2	-	-	RJPSF4	-
Compatible Mating Sleeve/Interconnect		ADAF1, ADAF2, or ADAF4-5
Fiber Optic Cannulae^c	Ceramic 10.5 mm Long Ferrule	CFMC22L02 CFMC22L05 CFMC22L10 CFMC22L20 CFMC22U-20	CFMC12L02 CFMC12L05 CFMC12L10 CFMC12L20 CFMC12U-20	CFMC52L02 CFMC52L05 CFMC52L10 CFMC52L20 CFMC52U-20	CFMC13L02 CFMC13L05 CFMC13L10 CFMC13L20	CFMC14L02 CFMC14L05 CFMC14L10 CFMC14L20 CFMC14U-20	CFMC54L02 CFMC54L05 CFMC54L10 CFMC54L20
Fiber Optic Cannulae^c	Stainless Steel 12.7 mm Long Ferrule	CFM22L02 CFM22L05 CFM22L10 CFM22L20 CFM22U-20	CFM12L02 CFM12L05 CFM12L10 CFM12L20 CFM12U-20	CFM52L02 CFM52L05 CFM52L10 CFM52L20 CFM52U-20	CFM13L02 CFM13L05 CFM13L10 CFM13L20	CFM14L02 CFM14L05 CFM14L10 CFM14L20 CFM14U-20	CFM15L02 CFM15L05 CFM15L10 CFM15L20
Items are compatible with each other when they are comprised of the same fiber type and listed in the same column. Patch cables for single source to single implant applications are highlighted in green above. Choose a patch cable with an input that matches your light source. Available cannulae are highlighted in orange of the table above. Cannulae within the same column are interchangeable.

Bilateral Stimulation

The ability to accurately and simultaneously direct light to multiple locations within a specimen is desired for many types of optogenetics experiments. For example, bilateral stimulation techniques typically target neurons in two spatially separated regions in order to induce a desired behavior. In more complex experiments involving the simultaneous inhibition and stimulation of neurons, delivering light of two different monochromatic wavelengths within close proximity enables the user to perform these experiments without implanting multiple cannulae, which can increase stress on the specimen.

Bilateral stimulation can be achieved with several different configurations depending on the application requirements. The sections below illustrate examples of different configurations using Thorlabs' optogenetics products.

Option 1: One Light Source to Two Cannula Implants Using Rotary Joint Splitter

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Click to See Ø1.25 mm (LC) Ferrule Components Recommended for Use with RJ2 Rotary Joint Splitter

Component Selection Table (Click Links for Item Description Popup)
Common Fiber Properties
Fiber Properties	Core Diameter	200 µm			400 µm
	Wavelength Range^a	400 - 700 nm	400 - 700 nm	400 - 700 nm	400 - 700 nm	400 - 700 nm
	NA	0.22	0.39	0.50	0.39	0.50
Input Patch Cables^b	Standard FC/PC Connectors	M122L01 M122L02 M122L05	M72L01 M72L02 M72L05	M123L01 M123L02	M74L01 M74L02 M74L05	M124L01 M124L02
Input Patch Cables^b	Hybrid SMA905 to FC/PC	M36L01	M75L01 M75L02	M129L01 M129L02	M76L01 M76L02	M131L01 M131L02
Rotary Joint		RJ2
Output Patch Cables	FC/PC to Ø1.25 mm (LC) Ferrule	M86L005 M86L01	M83L01 MR83L01	M73L01	M99L01	M127L01
Compatible Mating Sleeve/Interconnect		ADAL1, ADAL3, or ADAL4-5
Fiber Optic Cannulae^c	Ceramic 6.4 mm Long Ferrule	CFMLC22L02 CFMLC22L05 CFMLC22L10 CFMLC22L20 CFMLC22U-20	CFMLC12L02 CFMLC12L05 CFMLC12L10 CFMLC12L20 CFMLC12U-20	CFMLC52L02 CFMLC52L05 CFMLC52L10 CFMLC52L20 CFMLC52U-20	CFMLC14L02 CFMLC14L05 CFMLC14L10 CFMLC14L20 CFMLC14U-20	CFMLC15L02 CFMLC15L05 CFMLC15L10 CFMLC15L20
	Diffuser Tip (Ceramic 6.4 mm Long Ferrule)	-	CFDSB02 CFDSB05 CFDSB10 CFDSB20	-	-	-
	Ceramic 10.5 mm Long Ferrule	CFMXA02 CFMXA05 CFMXA10 CFMXA20	CFMXB02 CFMXB05 CFMXB10 CFMXB20	CFMXC02 CFMXC05 CFMXC10 CFMXC20	-	CFMXD02 CFMXD05 CFMXD10 CFMXD20
	Stainless Steel 6.4 mm Long Ferrule	CFML22L02 CFML22L05 CFML22L10 CFML22L20 CFML22U-20	CFML12L02 CFML12L05 CFML12L10 CFML12L20 CFML12U-20	CFML52L02 CFML52L05 CFML52L10 CFML52L20 CFML52U-20	CFML14L02 CFML14L05 CFML14L10 CFML14L20 CFML14U-20	CFML15L02 CFML15L05 CFML15L10 CFML15L20
Products in each column can be used with each other over the indicated wavelength range and is limited by the operating range of the RJ2 Rotary Joint Splitter. Individual products may be used outside this range; see product information for detailed specifications. Use a standard FC/PC patch cable to connect to an FC/PC-terminated light source. SMA905 to FC/PC hybrid patch cables should be used to connect to an SMA905-terminated light source. Available cannulae are highlighted in orange of the table above. Cannulae within the same column are interchangeable.

Click for Detials

Click to See Ø2.5 mm (FC) Ferrule Components Recommended for Use with RJ2 Rotary Joint Splitter

Component Selection Table (Click Links for Item Description Popup)
Common Fiber Properties
Fiber Properties	Core Diameter	200 µm			300 µm	400 µm
	Wavelength Range^a	400 - 700 nm	400 - 700 nm	400 - 700 nm	400 - 700 nm	400 - 700 nm	400 - 700 nm
	NA	0.22	0.39	0.50	0.39	0.39	0.50
Input Patch Cables	Standard FC/PC Connectors	M122L01 M122L02 M122L05	M72L01 M72L02 M72L05	M123L01 M123L02	M56L005 M56L01	M74L01 M74L02 M74L05	M124L01 M124L02
Input Patch Cables	Hybrid SMA905 to FC/PC	M36L01	M75L01 M75L02	M129L01 M129L02	M58L005 M58L01	M76L01 M76L02	M131L01 M131L02
Rotary Joint		RJ2
Output Patch Cables	FC/PC to Ø2.5 mm (FC) Ferrule	M80L005 M80L01	M81L005 M81L01 MR81L01	M104L01	M56L005 M56L01	M82L005 M82L01	M128L01
Compatible Mating Sleeve/Interconnect		ADAF1, ADAF2, or ADAF4-5
Fiber Optic Cannulae^c	Ceramic 10.5 mm Long Ferrule	CFMC22L02 CFMC22L05 CFMC22L10 CFMC22L20 CFMC22U-20	CFMC12L02 CFMC12L05 CFMC12L10 CFMC12L20 CFMC12U-20	CFMC52L02 CFMC52L05 CFMC52L10 CFMC52L20 CFMC52U-20	CFMC13L02 CFMC13L05 CFMC13L10 CFMC13L20	CFMC14L02 CFMC14L05 CFMC14L10 CFMC14L20 CFMC14U-20	CFMC54L02 CFMC54L05 CFMC54L10 CFMC54L20
Fiber Optic Cannulae^c	Stainless Steel 12.7 mm Long Ferrule	CFM22L02 CFM22L05 CFM22L10 CFM22L20 CFM22U-20	CFM12L02 CFM12L05 CFM12L10 CFM12L20 CFM12U-20	CFM52L02 CFM52L05 CFM52L10 CFM52L20 CFM52U-20	CFM13L02 CFM13L05 CFM13L10 CFM13L20	CFM14L02 CFM14L05 CFM14L10 CFM14L20 CFM14U-20	CFM15L02 CFM15L05 CFM15L10 CFM15L20
Products in each column can be used with each other over the indicated wavelength range and is limited by the operating range of the RJ2 Rotary Joint Splitter. Individual products may be used outside this range; see product information for detailed specifications. Use a standard FC/PC patch cable to connect to an FC/PC-terminated light source. SMA905 to FC/PC hybrid patch cables should be used to connect to an SMA905-terminated light source. Available cannulae are highlighted in orange of the table above. Cannulae within the same column are interchangeable.

Option 2: One or Two Light Sources to Two Cannula Implants

If the intent is for one LED source to connect to two cannulae for simultaneous light modulation, then a bifurcated fiber bundle can be used to split the light from the LED into each respective cannula. For dual wavelength stimulation (mixing two wavelengths in a single cannula) or a more controlled split ratio between cannula, one can use a multimode coupler to connect one or two LEDs to the cannulae. If one cable end is left unused, the spare coupler cable end may be terminated by a light trap. See the graphic and compatibility table below for the necessary cables and cannulae to create this setup. For LEDs and drivers, see below or the full web presentation.

Click on Each Component Below for More Information

Click to see Compatible Fiber Bundles, Coupler/Splitters, Cannulae, and Interconnects

Part Selection Table (Click Links for Item Description Popup)
Common Fiber Properties
Core Diameter		105 µm	200 µm						400 µm
Wavelength Range		400 - 2200 nm^a	400 - 1200 nm^a		400 - 900 nm^a				400 - 2200 nm
NA		0.22	0.22		0.39		0.50		0.39
Ferrule Style^b		LC (Ø1.25 mm)	LC (Ø1.25 mm)	FC (Ø2.5 mm)	LC (Ø1.25 mm)	FC (Ø2.5 mm)	LC (Ø1.25 mm)	FC (Ø2.5 mm)	LC (Ø1.25 mm)	FC (Ø2.5 mm)
Bifurcated Y-Cable^c	FC/PC Input	-	BFYL1LF01	BFYF1LF01	BFYL2LF01	BFYF2LF01	-	-	BFYL4LF01	BFYF4LF01
Bifurcated Y-Cable^c	SMA905 Input	-	BFYL1LS01	BFYF1LS01	BFYL2LS01	BFYF2LS01	-	-	BFYL4LS01	BFYF4LS01
1x2 Multimode Coupler^c	FC/PC Input	TM105FL1B	TM200FL1B	TM200FS1B	TT200FL1A	TT200FS1A	TH200FL1A	TH200FS1A	-	-
1x2 Multimode Coupler^c	SMA905 Input	TM105SL1B	TM200SL1B	TM200SS1B	TT200SL1A	TT200SS1A	TH200SL1A	TH200SS1A	-	-
2x2 Multimode Coupler^c	FC/PC Input	-	-	-	TT200FL2A	TT200FS2A	-	-	-	-
2x2 Multimode Coupler^c	SMA905 Input	-	-	-	TT200SL2A	TT200SS2A	-	-	-	-
Compatible Mating Sleeve/Interconnect		ADAL1 ADAL3 ADAL34-5	ADAL1 ADAL3 ADAL4-5	ADAF1 ADAF2 ADAF4-5	ADAL1 ADAL3 ADAL4-5	ADAF1 ADAF2 ADAF4-5	ADAL1 ADAL3 ADAL4-5	ADAF1 ADAF2 ADAF4-5	ADAL1 ADAL3 ADAL4-5	ADAF1 ADAF2 ADAF4-5
Fiber Optic Cannulae^d	Ceramic 6.4 mm Long Ferrule	CFMLC21L02 CFMLC21L05 CFMLC21L10 CFMLC21L20 CFMLC21U-20	CFMLC22L02 CFMLC22L05 CFMLC22L10 CFMLC22L20 CFMLC22U-20	-	CFMLC12L02 CFMLC12L05 CFMLC12L10 CFMLC12L20 CFMLC12U-20	-	CFMLC52L02 CFMLC52L05 CFMLC52L10 CFMLC52L20 CFMLC52U-20	-	CFMLC14L02 CFMLC14L05 CFMLC14L10 CFMLC14L20 CFMLC14U-20	-
	Diffuser Tip (Ceramic 6.4 mm Long Ferrule)	-	-	-	CFDSB02 CFDSB05 CFDSB10 CFDSB20	-	-	-	-	-
	Ceramic 10.5 mm Long Ferrule	-	CFMXA02 CFMXA05 CFMXA10 CFMXA20	CFMC22L02 CFMC22L05 CFMC22L10 CFMC22L20 CFMC22U-20	CFMXB02 CFMXB05 CFMXB10 CFMXB20	CFMC12L02 CFMC12L05 CFMC12L10 CFMC12L20 CFMC12U-20	CFMXC02 CFMXC05 CFMXC10 CFMXC20	CFMC52L02 CFMC52L05 CFMC52L10 CFMC52L20 CFMC52U-20	-	CFMC14L02 CFMC14L05 CFMC14L10 CFMC14L20 CFMC14U-20
	Stainless Steel	CFML21L02 CFML21L05 CFML21L10 CFML21L20 CFML21U-20	CFML22L02 CFML22L05 CFML22L10 CFML22L20 CFML22U-20	CFM22L02 CFM22L05 CFM22L10 CFM22L20 CFM22U-20	CFML12L02 CFML12L05 CFML12L10 CFML12L20 CFML12U-20	CFM12L02 CFM12L05 CFM12L10 CFM12L20 CFM12U-20	CFML52L02 CFML52L05 CFML52L10 CFML52L20 CFML52U-20	CFM52L02 CFM52L05 CFM52L10 CFM52L20 CFM52U-20	CFML14L02 CFML14L05 CFML14L10 CFML14L20 CFML14U-20	CFM14L02 CFM14L05 CFM14L10 CFM14L20 CFM14U-20

Products in this column can be used with each other over the indicated wavelength range. Individual products may be used outside this range; see product information for detailed specifications.
LC components have a Ø1.25 mm ferrule end while FC components have a Ø2.5 mm ferrule end. Items listed in the same "Ferrule Style" column are compatible with each other.
Optogenetics products for one or two light sources to two cannula implant applications are highlighted in green above. Choose a component with an input that matches your light source.
Available cannulae are highlighted in orange of the table above. Cannule within the same column are interchangeable.

Two Light Sources into One Dual-Core Cannula Implant

For bilateral stimulation applications where the two cannulas need to be placed in close proximity (within ~1 mm), Thorlabs offers dual-core patch cables and cannulae that are designed for this specific application. Each core is driven by a separate light source, enabling users to stimulate and/or supress nerve cells in the same region of the specimen. See the graphic and compatibility table below for the necessary cables and cannulae to create this setup. For LEDs and drivers, see below or the full web presentation.

Click on Each Component for More Information

Part Selection Table (Click Links for Item Description Popup)
Common Fiber Properties
Core Diameter		200 µm
Wavelength Range		400 - 2200 nm
NA		0.39
Fiber Type		FT200EMT
Ferrule Style^a		FC (Ø2.5 mm)
Dual-Core Patch Cable	FC/PC Input	BFY32FL1
Dual-Core Patch Cable	SMA905 Input	BFY32SL1
Compatible Mating Sleeve/Interconnect		ADAF1 ADAF2 ADAF4-5
Dual-Core Fiber Optic Cannulae^c	Stainless Steel	CFM32L10 CFM32L20

FC components have a Ø2.5 mm ferrule end.
Patch cables for dual light source to single implant applications are highlighted in green above. Choose a patch cable with an input that matches your light source.
Available cannulae are highlighted in orange of the table above. Cannule within the same column are interchangeable.

Popular Fiber-Coupled LEDs for Optogenetics
Item #	M470F3	M590F3
Center Wavelength	470 nm	590 nm
Bandwidth (FWHM)	20 nm	16 nm
Typical Output Spectrum (Click to Enlarge)
Ø200 µm Core Fiber Output (Typ.)^a	7.0 mW	1.5 mW
Ø400 µm Core Fiber Output (Typ.)^b	21.8 mW	4.6 mW
CW Drive Current (Max)	1.0 A	1.0 A
LED Forward Voltage	3.1 V	2.6 V
Typical Lifetime	>50,000 Hours	>10,000 Hours

Tested using MM Fiber with Ø200 µm core, 0.22 NA (Item # FG200UCC).
Tested using MM Fiber with Ø400 µm core, 0.39 NA (Item # FT400EMT).

Illumination

Click to Enlarge
M470F3

Fiber-Coupled LEDs and Drivers

Our fiber-coupled LEDs are ideal light sources for optogenetics applications. They feature a variety of wavelength choices and a convenient interconnection to optogenetics patch cables. Thorlabs offers fiber-coupled LEDs with nominal wavelengths ranging from 280 nm to 1050 nm. See the table to the right for the LEDs with the most popular wavelengths for optogenetics. A table of compatible LED drivers can be viewed by clicking below.

Click to See Compatible LED Drivers

Compatible Drivers^a	LEDD1B^b	DC2200^c	DC4100^c,d,e	DC4104^c,d,e
Click Photos to Enlarge
Main Driver Features	Very Compact Footprint 60 mm x 73 mm x 104 mm (W x H x D)	Touchscreen Interface with Internal and External Options for Pulsed and Modulated LED Operation	4 Channels^d	4 Channels^d
LED Driver Current Output (Max)	1.2 A	LED1 Terminal: 10.0 A LED2 Terminal: 2.0 A^f	1.0 A per Channel	1.0 A per Channel
LED Driver Forward Voltage (Max)	12 V	50 V	5 V	5 V
Modulation Frequency	0 to 5 kHz (External)	20 to 100 kHz (Internal)^h DC to 250 kHz (External)^g,h	0 to 100 kHz (External)^h Simultaneous Across all Channels	0 to 100 kHz (External)^h Independently Controlled Channels
External Control Interface(s)	Analog (BNC)	USB 2.0 and Analog (BNC)	USB 2.0 and Analog (BNC)	USB 2.0 and Analog (8-Pin)
EEPROM Compatible: Reads Out LED Data for LED Settings	-
LCD Display	-

Click on the item number link to view the complete presentation for each controller.
The preferred power supply (single channel or hub-based) depends on the end user's application and whether you already own compatible power supplies. To that end and in keeping with Thorlabs' green initiative, we do not ship the LEDD1B bundled with a power supply. This avoids the cost and inconvenience of receiving an unwanted single-channel supply if a hub-based system (Item # KCH301 or KCH601) would be more appropriate.
Automatically limits to LED's max current via EEPROM readout.
The DC4100 and DC4104 can power and control up to four LEDs simultaneously when used with the DC4100-HUB. The fiber-coupled LEDs on this page all require the DC4100-HUB when used with the DC4100 or DC4104.
These LED drivers have a maximum forward voltage rating of 5 V and can provide a maximum current of 1000 mA. As a result, they cannot be used to drive LEDs which have forward voltage ratings greater than 5 V. LEDs with maximum current ratings higher than 1.0 A can be driven using this driver, but will not reach full power.
The fiber-coupled LEDs sold above are compatible with the LED2 Terminal.
Small Signal Bandwidth: Modulation not exceeding 20% of full scale current. The driver accepts other waveforms, but the maximum frequency will be reduced.
The M565F3 and M595F2 LEDs produce light by stimulating emission from phosphor, which limits their modulation frequency range. These LEDs may not turn off completely when modulated above 10 kHz at duty cycles below 50%.

View All »Matching Part Numbers

Optogenetics Equipment and Custom Solutions

Thorlabs Optogenetics Equipment

Interactive Optogenetics System Schematic

Fiber Optic Cannulae

Two Methods of Use

Stereotaxic Cannula Holders and Adapter Arms

Cannula Implant Guides

Fiber Patch Cables

1x1 Rotary Joint for FC/PC Multimode Patch Cables

Interconnect and Mating Sleeves

Fiber Optic Couplers / Splitters

Rotary Joint Splitter

Light Sources

Cable and Cannula Building Supplies

Customizable Optogenetics Kits

For information concerning custom orders, pricing, and availability, please contact Tech Support.

Custom Fiber Optic Cannula

Optogenetics Selection Guide

Single-Site Stimulation

One Light Source to One Cannula Implant

Click to See Ø1.25 mm (LC) Ferrule Compatible Patch Cables, Cannulae, and Interconnects

Click to See Ø2.5 mm (FC) Ferrule Compatible Patch Cables, Cannulae, and Interconnects

Bilateral Stimulation

Option 1: One Light Source to Two Cannula Implants Using Rotary Joint Splitter

Click to See Ø1.25 mm (LC) Ferrule Components Recommended for Use with RJ2 Rotary Joint Splitter

Click to See Ø2.5 mm (FC) Ferrule Components Recommended for Use with RJ2 Rotary Joint Splitter

Option 2: One or Two Light Sources to Two Cannula Implants

Click to see Compatible Fiber Bundles, Coupler/Splitters, Cannulae, and Interconnects

Two Light Sources into One Dual-Core Cannula Implant

Illumination

Fiber-Coupled LEDs and Drivers

Click to See Compatible LED Drivers

For information concerning custom orders, pricing, and availability, please contact Tech Support .