Thorlabs Optogenetics Equipment

• Thorlabs' Optogenetics Equipment is used Extensively in Leading Optogenetics Labs
• Custom Optogenetics Equipment Built to Order
• Complete System Including Fiber Optic Cannulae, Fiber Patch Cables, and Light Sources
• Stock Components (Same Day Shipping)
• Fiber Optic Cannulae
• Stereotaxic Cannula Holders and Adapter Arms
• Cannula Implant Guides
• Fiber Optic Patch Cables
• Rotary Joint Fiber Optic Patch Cables
• Lightweight Patch Cables
• Rotary Joint
• Fiber Optic Interconnect and Mating Sleeves
• Fiber Optic Couplers/Splitters and Wideband Multimode Circulators (WMC)
• Rotary Joint Splitters
• LED and Laser Light Sources
• Complete Optogenetics Kits
• Next-Day Availability for Custom Patch Cable Orders Placed Before 2 PM EST

Thorlabs offers a full line of optogenetics equipment for in vivo stimulation, including implantable fiber optic cannulae, fiber optic patch cables and rotary joints, and LED and laser light sources. We are also well equipped to provide custom optogenetics packages including fiber-coupled light sources and custom-made cannulae. Please contact Tech Support for individual assistance regarding optogenetics equipment selection.

Interactive Optogenetics System Schematic

Click on the components or labels for more details about our optogenetics line of products. Contact Tech Support for more information about our expanding line of optogenetics products.

Figure 1.1  Optogenetics System Schematic

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Figure 1.3  Ferrule Patch Cables are ideal for connection to our Implantable Fiber Optic Cannulae.

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Figure 1.2  Thorlabs' Dual-Core Fiber Optic Patch Cable and Dual-Core Implantable Cannula enable light at different wavelengths to be inserted in close proximity.

Fiber Optic Cannulae

• Low-Profile Implantable Fiber Optic Cannulae
• Ø1.25 mm and Ø2.5 mm Ceramic and Stainless Steel Ferrules Available
• Ø200 µm, Ø300 µm, and Ø400 µm Multimode Optical Fiber Available
• Precision-Cleaved or Scissor-Cut Fiber End
• Custom Cannula Also Available (see the Custom Cannula Tab)

Thorlabs offers stock and custom fiber optic cannulae, which can be surgically mounted to the skull of the specimen using stereotactic guidance. Custom cannulae are available with a stainless steel or ceramic ferrules as well as an array of different fiber types, lengths, and end terminations. See the Custom Cannula tab for details.

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Figure 1.4  Fiber Optic Cannulae are available in various fiber lengths and ferrule sizes.

Two Methods of Use

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Figure 1.5  The cannula holder can be attached directly to an adapter arm by using the left-handed 8-32 tap at the end of the cannula holder.

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Figure 1.6  Alternatively, the XC-CLAMP can be used to allow for coarse height adjustment between the cannula holder and the XC7 adapter arm.

Stereotaxic Cannula Holders and Adapter Arms

• Cannula Holders Secure Ø1.25 mm or Ø2.5 mm Fiber Optic Cannulae During Implantation
• Requires Less Force to Use than Competing Solutions, Reducing Stress on the Specimen
• Ø5 mm and Ø7.9 mm Adapter Arms Provide Compatibility with Most Stereotaxic Equipment
• Adapter Clamp for Coarse Height Adjustment of Cannula Holder
• Stainless Steel Construction for Easy Sterilization

Thorlabs' Cannula Holders and Adapters are designed to securely hold a fiber optic cannula during implantation using a stereotaxic apparatus. For easy sterilization and repeated use, these holders and adapters are manufactured using stainless steel. The cannula holders feature an easy-to-use chuck that minimizes the stress on the specimen during implantation and when releasing the cannulae. For compatibility with most standard stereotaxic equipment, the cannula holders contain 8-32 threads that can accept our Ø5 mm and Ø7.9 mm adapter arms. Additionally, the cannula holders and adapter arms can also be used with the adapter clamp shown in Figure 1.6, which provides coarse height adjustment of a cannula holder and Ø7.9 mm adapter arm via two 1/4"-20 thumbscrews.

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Figure 1.9  Implant Guide Assembly

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Figure 1.8  Weep holes for epoxy to escape

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Figure 1.7  Mounting Surface of OGF Cannula Impant Guide

Cannula Implant Guides

• Improves Adhesion and Stability During Implantation
• Compatible with Ø1.25 mm and Ø2.5 mm Fiber Optic Cannulae with ≥5 mm Length
• Ø3.8 mm (OGL) or Ø5.1 mm (OGF) Mounting Surface with Grooved Ring for Dental Cement
• Lightweight Surgical Titanium Construction (≤0.11 g)
• Weep Holes for Glue and Epoxy to Secure a Cannula
• Compatible with Stereotaxic Cannula Holders

These Cannula Implant Guides are designed to provide guidance and stability for a fiber optic cannula during an implantation procedure. The bottom surface of each implant guide features a roughened surface and circular groove (see Figure 1.7) that increase the surface area available to dental cement and improves adhesion to the specimen. A 1.6 mm long protrusion on the implant guide helps stabilize the guide when implanted. Each implant is constructed using lightweight surgical titanium (≤0.11 g) which can be sterilized prior to use.

For best results when implanting a cannula, the OGL and OGF should be used with a cannula holder and stereotaxic guidance equipment. To affix the cannula within the implant guide, first insert the cannula into the receptacle of the implant guide. Then, add a small amount of cement or epoxy to the cannula via the two Ø0.8 mm weep holes (see Figure 1.8). Finally, attach the cannula ferrule to an XCL (Ø1.25 mm ferrule) or XCF (Ø2.5 mm ferrule) cannula holder (see Figure 1.9).

The OGL implant guide is compatible with our standard Ø1.25 mm cannulae (ceramic and stainless steel) and the OGF implant guide is compatible with our standard Ø2.5 mm cannulae (ceramic and stainless steel). When assembled, the length of the protruding fiber is reduced by 1 mm (Item # OGL) or 2 mm (Item # OGF); therefore, these implant guides cannot be used with our 2 mm long cannulae. Additionally, due to the fiber separation distance, the implant guides cannot be used with our dual-core cannulae.

Fiber Patch Cables

Fiber Optic Rotary Joint Patch Cables

• Articulated Rotary Joint Prevents Fiber Damage Caused by Moving Specimen
• Integrated Ø200 µm or Ø400 µm Core Fiber Patch Cables
• Stainless Steel Armor on Specimen Side Available for Ø200 µm Patch Cables with Ø2.5 mm Ferrule Ends
• Single Cable Connects Cannula and Light Source in Optogenetics Experiments
• Extremely Smooth Rotation
• SM05-Threaded Housing for Secure Mounting

Our articulated fiber optic patch cables feature a rotary joint interface that allows the cable to freely rotate, reducing damage in optogenetics experiments. They provide a complete solution for connecting the light source to an implanted fiber optic cannula and are compatible with all Thorlabs light sources and optogenetics equipment.

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Figure 1.10  RJPFF2 Rotary Joint Patch Cable

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Figure 1.11  Rotary Joint Detail

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Figure 1.12  Ø1.25 mm Ferrule Optogenetics Patch Cable

Standard Lightweight Fiber Optic Patch Cables

• Large Selection of Multimode Fiber Patch Cables Ideal for Optogenetics
• Cables are Compatible with Ø1.25 mm and Ø2.5 mm Ferrule Cannulae
• Cables are Lightweight and Flexible for Specimen Mobility

Our optogenetics patch cables can be used to connect a light source to a fiber optic implantable cannulae. We offer small diameter fiber that minimizes tissue damage, as well as extra lightweight cables for Ø1.25 mm cannulae.

Specialty Fiber Patch Cables

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Figure 1.13  Custom 7 to 1 Fan Out Cable

• Extensive Custom Cable Capabilities and In-House Fiber Manufacturing
• Examples of Custom Optogenetics Cables Include:
• 7 to 1 Fan-Out Cable for Incorporating Multiple Light Sources into a Single Probe
• Stainless Steel Armored Cable for Protection from Specimen Damage
• See the Custom Cables Tab, or Contact Tech Support to Order a Custom Cable

We can custom fabricate cables, including armored cable for protection from specimen damage and fan out cables for incorporating multiple light sources into one fiber optic implant. See the Custom Cables tab for details.

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Figure 1.14  The RJ1 rotary joint has terminated ends and accepts a wide variety of FC/PC patch cables.

1x1 Rotary Joint for FC/PC Multimode Patch Cables

• Rotary Joint Protects Against Fiber Damage Caused by Moving Specimen
• Consistent Performance Over 400 - 700 nm Wavelength Range
• Low Transmission Variation During Rotation
• Recommended for ≥Ø200 µm Core, 0.22 to 0.50 NA Patch Cables
• Tested and Designed for Use with a Multimode Laser or Fiber-Coupled LED

Thorlabs' RJ1 1x1 Rotary Joint for FC/PC Multimode Patch Cables is a single input and output rotary joint with low rotational variation. Designed for use in optogenetics, the rotary interface allows patch cables to rotate freely when attached to a moving specimen, reducing the risk of both fiber damage and intensity fluctuations. The input and output patch cables are not permanently attached to the rotary joint, and, as a result, can be selected with a specific core size, NA, and jacketing type to optomize an experiment. This also allows cables to be easily replaced if fibers are damaged. For best performance, we recommend using multimode fibers with a core diameter ≥Ø200 µm and NA between 0.22 to 0.50. Thorlabs can provide custom rotary joints that are aligned and optimized using other patch cables or light sources; please contact Tech Support with inquiries.

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Figure 1.15  The ADAL1 Mating Sleeve is designed to mate Ø1.25 mm ferrule cannulae and patch cables.

Interconnect and Mating Sleeves

• Ceramic Mating Sleeves for Ø1.25 mm or Ø2.5 mm Bare Ferrules (Sold Individually or in Packs of 5)
• Quick-Release Interconnect for Mating Ø1.25 mm or Ø2.5 mm Ferrule Patch Cables to Cannulae
• Compatible with Stainless Steel and Ceramic (Zirconia) Ferrules

Thorlabs offers interconnects and mating sleeves for making connections between our line of optogenetics patch cables and fiber optic cannulae. These ferrule mating components provide low-loss coupling and are compatible with both stainless steel and ceramic (zirconia) ferrules. Interconnects are designed to facilitate easy connections and disconnections from an implanted cannula, requiring >80% less force to disconnect compared to mating sleeves. On the other hand, mating sleeves are preferred for very lightweight (~0.18 g), low-profile connections between a patch cable and cannula.

Fused Fiber Optic Couplers / Splitters and Wideband Multimode Circulators / Combiners

Thorlabs multimode fiber couplers are optimized for optogenetics applications such as bilateral stimulation, where one light source is used to illuminate two fiber optic implants placed close together in the specimen. Couplers are available from stock with 1x2 and 2x2 configurations. Our couplers have SMA905 or FC/PC connectors on the input legs for compatibility with fiber-coupled LED and laser light sources. They are available with Ø2.5 mm ferrule ends on the output legs for direct connection to a fiber optic cannula, or with standard SMA905 or FC/PC connectors for use with other patch cables, such as our rotary joint cables featured above.

Thorlabs also offers wideband multimode circulators (WMC), which can be used to combine different wavelength light sources into a single output with greater throughput than a 2x2 coupler (see Figure 1.18). They can also be used as a circulator, enabling high efficiency transfer from port 1 to port 2 as well as bidirectional multimode transmission between port 2 and port 3. These fused fiber WMCs are available with SMA905 or FC/PC connectors for compatibility with fiber-coupled LED and laser light sources.

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Figure 1.17  2x2 Multimode Fiber Coupler

Figure 1.18  WMCs in series can combine multiple light sources by injecting them into port 1 (blue). Any signal returned through port 2 (white) will exit port 3 (red).

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Figure 1.19  Schematic illustrates the input and output ports of the RJ2 1x2 rotary joint.

Rotary Joint Splitter

• Rotary Joint Protects Against Fiber Damage Caused by Moving Specimen
• 400 – 700 nm Wavelength Range
• 50:50 Intensity Split of Input Light
• Low Transmission Variation During Rotation
• Recommended for ≥Ø200 µm Core, 0.22 to 0.50 NA Patch Cables
• Tested and Designed for Use with a Multimode Laser or Fiber-Coupled LED

Thorlabs' RJ2 1x2 Rotary Joint Splitter is designed for optogenetics applications and is used to split light from a single input evenly between two outputs. The rotary joint interface allows connected patch cables to freely rotate, reducing the risk of fiber damage caused by a moving specimen. The rotary joint accepts any FC/PC-terminated patch cable, such as our optogenetics, multimode, and hybrid patch cables. For best performance, we recommend using multimode patch cables with a TECS-clad fiber, core diameter ≥Ø200 µm, and NA between 0.22 to 0.50. Thorlabs can provide custom rotary joint splitters that are aligned and optimized using other patch cables or light sources; please contact Tech Support with inquiries.

Light Sources

Thorlabs offers a variety of fiber-coupled light sources that can be used for in vivo stimulation. Our Fiber-Coupled LEDs offer a durable, economic solution with a variety of wavelength choices. Our Fiber-Coupled Lasers, Pigtailed Laser Diodes, and Benchtop Laser Diodes provide higher power at the cannula tip, and our Multichannel Light Source and Chrolis™ Light Source offer a variety of wavelengths in compact units.

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Figure 1.21  Multimode Optical Fiber

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Figure 1.20  SMA Connector Components

Cable and Cannula Building Supplies

• Bare Optical Fiber, Ferrules, Tubing, Connectors, and Tools
• Build Custom Cannulae and Fiber Optic Patch Cables
• Connectorization Kit Provides all Necessary Tools
• Complete Connectorization Instructions Available for Download

Thorlabs stocks individual components for building custom fiber optic cannulae and patch cables, including optical fiber, ferrules, connectors, tubing, and connectorization tools. Our FN96A connectorization manual, which is free to download, gives clear instructions on how to add connectors to optical fiber.

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Figure 1.22  Example Kit with Ø400 µm Core Fiber, Ø2.5 mm Ferrules, and Rotary Joint Patch Cable

Customizable Optogenetics Kits

• Complete Fiber Optics Setup
• Substitute or Remove Items for Tailored Use
• LED, Patch Cable, Cannulae, and Accessories
• Ferrule Options:
• Ø1.25 mm Ferrules (Ø200 or Ø400 µm Core)
• Ø2.5 mm Ferrules (Ø200 or Ø400 µm Core)
• Patch Cable Options
  • Standard Lightweight Patch Cable, 1 m Long
  • Patch Cable with Integrated Rotary Joint, 3 m Long
• Multiple Lengths of Cleaved Cannulae
• Certain Kits Include Uncleaved Cannulae and Cleaving Tools
• Cannula Holders for Stereotaxic Implantation
• Cleaning Supplies

Thorlabs' optogenetics equipment is available in complete, ready-to-use kits. These optogenetics kits are comprised of essential supplies to establish and maintain optogenetics experiments; kit contents may be substituted or removed to suit individual needs. Each kit includes a 470 nm Fiber-Coupled LED with driver, lightweight patch cables, interconnect and mating sleeves, cannulae, and fiber handling and maintenance tools. We offer kits with Ø200 µm or Ø400 µm fiber components and Ø1.25 mm or Ø2.5 mm ferrules.

Optogenetics Selection Guide

Thorlabs offers a wide range of optogenetics components; the compatibility of these products in select standard configurations is discussed in detail here. Please contact Technical Support for assistance with items outside the scope of this guide, including custom fiber components for optogenetics.

Single-Site Stimulation

One Light Source to One Cannula Implant

The most straightforward method for in vivo light stimulation of a specimen is to use a single fiber optic with a single LED light source. The single wavelength LED is powered by an LED driver, and then the illumination output is fiber-coupled into a patch cable, which connects to the implanted cannula. See the expandable compatibility tables for the necessary patch cables and cannulae to create this setup. To choose the appropriate LED and driver, see below or the full web presentation.

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Click to See Ø1.25 mm (LC) Ferrule Compatible Patch Cables, Cannulae, and Interconnects

Component Selection Table (Click Links for Item Description Popup)
Fiber Type		FG105LCA	FG200UCC	FT200EMT	FP200URT	FT400EMT	FP400URT
Fiber Type Specs	Core Diameter	105 µm	200 µm			400 µm
	Wavelength Range	400 - 2400 nm	250 - 1200 nm	400 - 2200 nm	300 - 1200 nm	400 - 2200 nm	300 - 1200 nm
	NA	0.22	0.22	0.39	0.50	0.39	0.50
Patch Cablesb	Standard FC/PC Input	M61L01	M86L005 M86L01	M83L01 MR83L01	M73L01	M99L01	M127L01
	Standard SMA905 Input	M63L01	M87L005 M87L01	M89L01 MR89L01	M95L01	M98L01	M125L01
	Rotary Joint FC/PC Input	-	-	RJPFL2	-	RJPFL4	-
	Rotary Joint SMA905 Input	-	-	RJPSL2	-	RJPSL4	-
Compatible Mating Sleeve/Interconnect		ADAL1, ADAL3, or ADAL4-5
Fiber Optic Cannulaec	Ceramic 6.4 mm Long Ferrule	CFMLC21L02 CFMLC21L05 CFMLC21L10 CFMLC21L20 CFMLC21U-20	CFMLC22L02 CFMLC22L05 CFMLC22L10 CFMLC22L20 CFMLC22U-20	CFMLC12L02 CFMLC12L05 CFMLC12L10 CFMLC12L20 CFMLC12U-20	CFMLC52L02 CFMLC52L05 CFMLC52L10 CFMLC52L20 CFMLC52U-20	CFMLC14L02 CFMLC14L05 CFMLC14L10 CFMLC14L20 CFMLC14U-20	CFMLC15L02 CFMLC15L05 CFMLC15L10 CFMLC15L20
	Diffuser Tip (Ceramic 6.4 mm Long Ferrule)	-	-	CFDSB02 CFDSB05 CFDSB10 CFDSB20	-	-	-
	Ceramic 10.5 mm Long Ferrule	-	CFMXA02 CFMXA05 CFMXA10 CFMXA20	CFMXB02 CFMXB05 CFMXB10 CFMXB20	CFMXC02 CFMXC05 CFMXC10 CFMXC20	-	CFMXD02 CFMXD05 CFMXD10 CFMXD20
	Stainless Steel 6.4 mm Long Ferrule	CFML21L02 CFML21L05 CFML21L10 CFML21L20 CFML21U-20	CFML22L02 CFML22L05 CFML22L10 CFML22L20 CFML22U-20	CFML12L02 CFML12L05 CFML12L10 CFML12L20 CFML12U-20	CFML52L02 CFML52L05 CFML52L10 CFML52L20 CFML52U-20	CFML14L02 CFML14L05 CFML14L10 CFML14L20 CFML14U-20	CFML15L02 CFML15L05 CFML15L10 CFML15L20
Items are compatible with each other when they are comprised of the same fiber type and listed in the same column. Patch cables for single source to single implant applications are highlighted in green. Choose a patch cable with an input that matches your light source. Available cannulae are highlighted in orange. Cannulae within the same column are interchangeable.

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Click to See Ø2.5 mm (FC) Ferrule Compatible Patch Cables, Cannulae, and Interconnects

Component Selection Table (Click Links for Item Description Popup)
Fiber Type		FG200UCC	FT200EMT	FP200URT	FT300EMT	FT400EMT	FP400URT
Fiber Type Specs	Core Diameter	200 µm			300 µm	400 µm
	Wavelength Range	250 - 1200 nm	400 - 2200 nm	300 - 1200 nm	400 - 2200 nm	400 - 2200 nm	300 - 1200 nm
	NA	0.22	0.39	0.50	0.39	0.39	0.50
Patch Cablesb	Standard FC/PC Input	M80L005 M80L01	M81L005 M81L01 MR81L01	M104L01	M56L005 M56L01	M82L005 M82L01	M128L01
	Standard SMA905 Input	M84L005 M84L01	M77L005 M77L01 MR77L01	M106L01	M58L005 M58L01	M79L005 M79L01	M126L01
	Rotary Joint FC/PC Input	-	RJAFF2 RJPFF2	-	-	RJPFF4	-
	Rotary Joint SMA905 Input	-	RJASF2 RJPSF2	-	-	RJPSF4	-
Compatible Mating Sleeve/Interconnect		ADAF1, ADAF2, or ADAF4-5
Fiber Optic Cannulaec	Ceramic 10.5 mm Long Ferrule	CFMC22L02 CFMC22L05 CFMC22L10 CFMC22L20 CFMC22U-20	CFMC12L02 CFMC12L05 CFMC12L10 CFMC12L20 CFMC12U-20	CFMC52L02 CFMC52L05 CFMC52L10 CFMC52L20 CFMC52U-20	CFMC13L02 CFMC13L05 CFMC13L10 CFMC13L20	CFMC14L02 CFMC14L05 CFMC14L10 CFMC14L20 CFMC14U-20	CFMC54L02 CFMC54L05 CFMC54L10 CFMC54L20
	Stainless Steel 12.7 mm Long Ferrule	CFM22L02 CFM22L05 CFM22L10 CFM22L20 CFM22U-20	CFM12L02 CFM12L05 CFM12L10 CFM12L20 CFM12U-20	CFM52L02 CFM52L05 CFM52L10 CFM52L20 CFM52U-20	CFM13L02 CFM13L05 CFM13L10 CFM13L20	CFM14L02 CFM14L05 CFM14L10 CFM14L20 CFM14U-20	CFM15L02 CFM15L05 CFM15L10 CFM15L20
Items are compatible with each other when they are comprised of the same fiber type and listed in the same column. Patch cables for single source to single implant applications are highlighted in green. Choose a patch cable with an input that matches your light source. Available cannulae are highlighted in orange. Cannulae within the same column are interchangeable.

Multilateral Stimulation

The ability to accurately and simultaneously direct light to multiple locations within a specimen is desired for many types of optogenetics experiments. For example, bilateral stimulation techniques typically target neurons in two spatially separated regions in order to induce a desired behavior. In more complex experiments involving the simultaneous inhibition and stimulation of neurons, delivering light of two different monochromatic wavelengths within close proximity enables the user to perform these experiments without implanting multiple cannulae, which can increase stress on the specimen.

Multilateral stimulation can be achieved with several different configurations depending on the application requirements. The sections below illustrate examples of different configurations using Thorlabs' optogenetics products.

Option 1: One Light Source to Two Cannula Implants Using Rotary Joint Splitter

Thorlabs' RJ2 1x2 Rotary Joint Splitter is designed for optogenetics applications and is used to split light from a single input evenly between two outputs. The rotary joint interface allows connected patch cables to freely rotate, reducing the risk of fiber damage caused by a moving specimen. See the expandable compatibility table for the necessary cables and cannulae to create this setup. For LEDs and drivers, see below or the full web presentation.

Click for Details

Click to See Ø1.25 mm (LC) Ferrule Components Recommended for Use with RJ2 Rotary Joint Splitter

Component Selection Table (Click Links for Item Description Popup)
Common Fiber Properties
Fiber Properties	Core Diameter	200 µm			400 µm
	Wavelength Rangea	400 - 700 nm	400 - 700 nm	400 - 700 nm	400 - 700 nm	400 - 700 nm
	NA	0.22	0.39	0.50	0.39	0.50
Input Patch Cablesb	Standard FC/PC Connectors	M122L01 M122L02 M122L05	M72L01 M72L02 M72L05	M123L01 M123L02	M74L01 M74L02 M74L05	M124L01 M124L02
	Hybrid SMA905 to FC/PC	M36L01	M75L01 M75L02	M129L01 M129L02	M76L01 M76L02	M131L01 M131L02
Rotary Joint		RJ2
Output Patch Cables	FC/PC to Ø1.25 mm (LC) Ferrule	M86L005 M86L01	M83L01 MR83L01	M73L01	M99L01	M127L01
Compatible Mating Sleeve/Interconnect		ADAL1, ADAL3, or ADAL4-5
Fiber Optic Cannulaec	Ceramic 6.4 mm Long Ferrule	CFMLC22L02 CFMLC22L05 CFMLC22L10 CFMLC22L20 CFMLC22U-20	CFMLC12L02 CFMLC12L05 CFMLC12L10 CFMLC12L20 CFMLC12U-20	CFMLC52L02 CFMLC52L05 CFMLC52L10 CFMLC52L20 CFMLC52U-20	CFMLC14L02 CFMLC14L05 CFMLC14L10 CFMLC14L20 CFMLC14U-20	CFMLC15L02 CFMLC15L05 CFMLC15L10 CFMLC15L20
	Diffuser Tip (Ceramic 6.4 mm Long Ferrule)	-	CFDSB02 CFDSB05 CFDSB10 CFDSB20	-	-	-
	Ceramic 10.5 mm Long Ferrule	CFMXA02 CFMXA05 CFMXA10 CFMXA20	CFMXB02 CFMXB05 CFMXB10 CFMXB20	CFMXC02 CFMXC05 CFMXC10 CFMXC20	-	CFMXD02 CFMXD05 CFMXD10 CFMXD20
	Stainless Steel 6.4 mm Long Ferrule	CFML22L02 CFML22L05 CFML22L10 CFML22L20 CFML22U-20	CFML12L02 CFML12L05 CFML12L10 CFML12L20 CFML12U-20	CFML52L02 CFML52L05 CFML52L10 CFML52L20 CFML52U-20	CFML14L02 CFML14L05 CFML14L10 CFML14L20 CFML14U-20	CFML15L02 CFML15L05 CFML15L10 CFML15L20
Products in each column can be used with each other over the indicated wavelength range and is limited by the operating range of the RJ2 Rotary Joint Splitter. Individual products may be used outside this range; see product information for detailed specifications. Use a standard FC/PC patch cable to connect to an FC/PC-terminated light source. SMA905 to FC/PC hybrid patch cables should be used to connect to an SMA905-terminated light source. Available cannulae are highlighted in orange. Cannulae within the same column are interchangeable.

Click for Detials

Click to See Ø2.5 mm (FC) Ferrule Components Recommended for Use with RJ2 Rotary Joint Splitter

Component Selection Table (Click Links for Item Description Popup)
Common Fiber Properties
Fiber Properties	Core Diameter	200 µm			300 µm	400 µm
	Wavelength Rangea	400 - 700 nm	400 - 700 nm	400 - 700 nm	400 - 700 nm	400 - 700 nm	400 - 700 nm
	NA	0.22	0.39	0.50	0.39	0.39	0.50
Input Patch Cables	Standard FC/PC Connectors	M122L01 M122L02 M122L05	M72L01 M72L02 M72L05	M123L01 M123L02	M56L005 M56L01	M74L01 M74L02 M74L05	M124L01 M124L02
	Hybrid SMA905 to FC/PC	M36L01	M75L01 M75L02	M129L01 M129L02	M58L005 M58L01	M76L01 M76L02	M131L01 M131L02
Rotary Joint		RJ2
Output Patch Cables	FC/PC to Ø2.5 mm (FC) Ferrule	M80L005 M80L01	M81L005 M81L01 MR81L01	M104L01	M56L005 M56L01	M82L005 M82L01	M128L01
Compatible Mating Sleeve/Interconnect		ADAF1, ADAF2, or ADAF4-5
Fiber Optic Cannulaec	Ceramic 10.5 mm Long Ferrule	CFMC22L02 CFMC22L05 CFMC22L10 CFMC22L20 CFMC22U-20	CFMC12L02 CFMC12L05 CFMC12L10 CFMC12L20 CFMC12U-20	CFMC52L02 CFMC52L05 CFMC52L10 CFMC52L20 CFMC52U-20	CFMC13L02 CFMC13L05 CFMC13L10 CFMC13L20	CFMC14L02 CFMC14L05 CFMC14L10 CFMC14L20 CFMC14U-20	CFMC54L02 CFMC54L05 CFMC54L10 CFMC54L20
	Stainless Steel 12.7 mm Long Ferrule	CFM22L02 CFM22L05 CFM22L10 CFM22L20 CFM22U-20	CFM12L02 CFM12L05 CFM12L10 CFM12L20 CFM12U-20	CFM52L02 CFM52L05 CFM52L10 CFM52L20 CFM52U-20	CFM13L02 CFM13L05 CFM13L10 CFM13L20	CFM14L02 CFM14L05 CFM14L10 CFM14L20 CFM14U-20	CFM15L02 CFM15L05 CFM15L10 CFM15L20
Products in each column can be used with each other over the indicated wavelength range and is limited by the operating range of the RJ2 Rotary Joint Splitter. Individual products may be used outside this range; see product information for detailed specifications. Use a standard FC/PC patch cable to connect to an FC/PC-terminated light source. SMA905 to FC/PC hybrid patch cables should be used to connect to an SMA905-terminated light source. Available cannulae are highlighted in orange. Cannulae within the same column are interchangeable.

Option 2: One or Two Light Sources to Two Cannula Implants

If the intent is for one LED source to connect to two cannulae for simultaneous light modulation, then a bifurcated fiber bundle can be used to split the light from the LED into each respective cannula. For dual wavelength stimulation (mixing two wavelengths in a single cannula) or a more controlled split ratio between cannula, one can use a multimode coupler to connect one or two LEDs to the cannulae. If one cable end is left unused, the spare coupler cable end may be terminated by a light trap. See the expandable compatibility table for the necessary cables and cannulae to create this setup. For LEDs and drivers, see below or the full web presentation.

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Option 3: One Light Sources to Seven Cannula Implants

If the intent is for one LED source to connect to seven cannulae for simultaneous light modulation, then a 1-to-7 fiber bundle can be used to split the light from the LED into each respective cannula. See the expandable compatibility table for the necessary cables and cannulae to create this setup. For LEDs and drivers, see below or the full web presentation.

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Two Light Sources into One Dual-Core Cannula Implant

For bilateral stimulation applications where the two cannulas need to be placed in close proximity (within ~1 mm), Thorlabs offers dual-core patch cables and cannulae that are designed for this specific application. Each core is driven by a separate light source, enabling users to stimulate and/or supress nerve cells in the same region of the specimen. See the expandable compatibility table for the necessary cables and cannulae to create this setup. For LEDs and drivers, see below or the full web presentation.

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Illumination

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Figure 93B  M405F3 405 nm
Fiber-Coupled LED

Fiber-Coupled LEDs and Drivers

Our fiber-coupled LEDs are ideal light sources for optogenetics applications. They feature a variety of wavelength choices and a convenient interconnection to optogenetics patch cables. Thorlabs offers fiber-coupled LEDs with nominal wavelengths ranging from 280 nm to 1050 nm. See Table 93A for the LEDs with the most popular wavelengths for optogenetics. See the expandable table for a list of compatible LED drivers.

Click to See Compatible LED Drivers

Compatible Driversa	UPLEDb	LEDD1Bc	DC2200b	DC4100b,d,e	DC4104b,d,e
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Main Driver Features	USB-Controlled	Very Compact Footprint 60 mm x 73 mm x 104 mm (W x H x D)	Touchscreen Interface with Internal and External Options for Pulsed and Modulated LED Operation	4 Channelsd	4 Channelsd
LED Driver Current Output (Max)	1.2 A	1.2 A	LED1 Terminal: 10.0 A LED2 Terminal: 2.0 Af	1.0 A per Channel	1.0 A per Channel
LED Driver Forward Voltage (Max)	8 V	12 V	50 V	5 V	5 V
Modulation Frequency	-	0 to 5 kHz (External)	20 to 100 kHz (Internal)h DC to 250 kHz (External)g,h	0 to 100 kHz (External)h Simultaneous Across all Channels	0 to 100 kHz (External)h Independently Controlled Channels
External Control Interface(s)	USB 2.0	Analog (BNC)	USB 2.0 and Analog (BNC)	USB 2.0 and Analog (BNC)	USB 2.0 and Analog (8-Pin)
EEPROM Compatible: Reads Out LED Data for LED Settings		-
LCD Display	-	-

• Click on the item number link to view the complete presentation for each controller.
• Automatically limits to LED's max current via EEPROM readout.
• The preferred power supply (single channel or hub-based) depends on the end user's application and whether you already own compatible power supplies. To that end and in keeping with Thorlabs' green initiative, we do not ship the LEDD1B bundled with a power supply. This avoids the cost and inconvenience of receiving an unwanted single-channel supply if a hub-based system (Item #s KEH3 or KEH6) would be more appropriate.
• The DC4100 and DC4104 can power and control up to four LEDs simultaneously when used with the DC4100-HUB. The fiber-coupled LEDs on this page all require the DC4100-HUB when used with the DC4100 or DC4104.
• These LED drivers have a maximum forward voltage rating of 5 V and can provide a maximum current of 1000 mA. As a result, they cannot be used to drive LEDs which have forward voltage ratings greater than 5 V. LEDs with maximum current ratings higher than 1.0 A can be driven using this driver, but will not reach full power.
• The fiber-coupled LEDs sold above are compatible with the LED2 Terminal.
• Small Signal Bandwidth: Modulation not exceeding 20% of full scale current. The driver accepts other waveforms, but the maximum frequency will be reduced.
• The M565F3 and M595F2 LEDs produce light by stimulating emission from phosphor, which limits their modulation frequency range. These LEDs may not turn off completely when modulated above 10 kHz at duty cycles below 50%.