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Scientific Cameras: OEM and Manufacturing Capabilities


Scientific Cameras: OEM and Manufacturing Capabilities


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Standard, Customized, or OEM Cameras and Software for a Range of Applications (Click Each Image for Details)
Intracellular Dynamics Brightfield Microscopy Opthalmology Fluorescence Microscopy Multispectral imaging Neuroscience SEM
Intracellular Dynamics Brightfield Microscopy Ophthalmology (NIR) Fluorescence Microscopy Multispectral Imaging Neuroscience SEM/TEM
Thorlabs' Scientific Cameras Recommended for Each Application Above
Quantalux™ sCMOS
1.4 Megapixel
Fast Frame Rate
4 Megapixel
8 Megapixel
Quantalux™ sCMOS
1.4 Megapixel
Quantalux™ sCMOS
4 Megapixel
1.4 Megapixel
Quantalux™ sCMOS
4 Megapixel
1.4 Megapixel
Quantalux™ sCMOS
1.4 Megapixel
1.4 Megapixel
4 Megapixel
Fast Frame Rate

The scientists and engineers at Thorlabs' Scientific Imaging (TSI) Group in Austin, Texas work in a multidisciplinary environment to develop challenging circuit designs, innovative optical and mechanical solutions, firmware, and host side software in a camera platform that can be used with a variety of imagers. Our unique and diverse skill base gives us the ability to customize low-noise, high-performance scientific cameras and interface devices that fit your needs.

We provide a variety of standard camera offerings as well as cameras customized to almost any need for OEM or system designers. All cameras can be designed for low-light and/or high-speed imaging systems and tailored to meet stringent size, environmental, and packaging requirements. A full-featured and well-documented API, included with our cameras, makes it convenient to develop fully customized applications in an efficient manner, while also providing the ability to migrate through our product line without having to rewrite an application. Our standard sCMOS, CCD, and fast frame rate cameras have been deployed in numerous applications as shown in the photos above and the list below.

Applications

  • High-Content and High-Throughput Screening
  • Electron Microscopy (TEM/SEM)
  • NIR Imaging
  • Multispectral Imaging
  • Fluorescence Microscopy
  • In Vivo and In Vitro Imaging
  • NIR/DIC Patch Clamping
  • Ophthalmic Imaging
Scientific Camera
Thorlabs Expertise
Skillsets Developed Over 20 Years
Scientific Camera
Custom/OEM Cameras
Create a Unique Solution
Scientific Camera
Standard Cameras
Growing Portfolio of Cameras Developed by Thorlabs
Scientific Camera
Click to Enlarge

Camera Housings of Our Compact Scientifc and Scientific CCD Cameras

Features

  • Versions Available:
    • sCMOS: Quantalux™ 2.1 MP Monochrome Sensor
    • CMOS: 5 MP and 8.9 MP Monochrome or Color Sensors
    • CCD: Fast Frame Rate VGA, 1.4 MP, 4 MP, and 8 MP Monochrome or Color Sensors
  • High Quantum Efficiency
  • Low Read Noise
  • Software-Selectable Pixel Clock Speed
  • Region-of-Interest (ROI) and Binning Modes
  • 32- and 64-Bit Windows® 7, 8.1, or 10 Support
  • Asynchronous, Triggered, and Bulb Exposure Modes
  • Support for MATLAB and LabVIEW
  • All Models Supported by Full-Featured API / SDK

Our scientific cameras utilize high quantum efficiency, low noise sensors, which make them ideal for multispectral imaging, fluorescence microscopy, and other high-performance imaging techniques. Our Compact Scientific Cameras, including the Quantalux™ sCMOS camera, are housed in compact, passively cooled housings. Our Scientific CCD cameras are available with TE-cooled and non-cooled housings. See below for more details on the camera packages offered.

Camera Type Quantalux™ 2.1 MP sCMOS 5 MP CMOS 8.9 MP CMOS
Item # Monochrome: CS2100M-USB Monochrome: CS505MU
Color: CS505CU
Monochrome: CS895MU
Color: CS895CU
Electronic Shutter Rolling Shuttera Global Shutter
Sensor Type sCMOS CMOS
Number of Pixels (H x V) 1920 x 1080 2448 x 2048 4096 x 2160
Pixel Size 5.04 µm x 5.04 µm 3.45 µm x 3.45 µm
Optical Format 2/3"
(11 mm Diagonal)
2/3" Format
(11 mm Diagonal)
1" Format
(16 mm Diagonal)
Peak Quantum Efficiency
(Click for Plot)
Monochrome: 61% (at 600 nm) Monochrome: 79% (at 600 nm)
Color: Click for Plot
Monochrome: 71% (at 600 nm)
Color: Click for Plot
Max Frame Rate
(Full Sensor)
50 fps 35 fps 20.8 fps
Read Noise <1 e- Median, <1.5 e- RMS <2.5 e- RMS
Digital Output (Max) 16 Bit 12 Bit
Available Fanless Cooling Passive Thermal Management
PC Interface USB 3.0
Housing Dimensions
(Click to Enlarge)
Compact Scientific Camera
Typical Applications Fluorescence Microscopy
VIS/NIR Imaging
Quantum Dots
Autofluorescence
Materials Inspection
Multispectral Imaging
Fluorescence In Situ Hybridization (FISH)
Fluorescence Microscopy
Immunohistochemistry (IHC)
Machine Vision
Inspection
Fluorescence Microscopy
Immunohistochemistry (IHC)
Large FOV Slide Imaging
Machine Vision
Inspection
  • Rolling Shutter with Equal Exposure Pulse (EEP) Mode for Synchronizing the Camera and Light Sources for Even Illumination
Camera Type Fast Frame Rate VGA CCD 1.4 MP CCD 4 MP CCD 8 MP CCD
Item # Prefix Monochrome:
340M
UV-Enhanced
Monochrome:
340UV
Monochrome: 1501M
Color: 1501C
Monochrome: 4070M
Color: 4070C
Monochrome: 8051M
Color: 8051C
Electronic Shutter Global Shutter
Sensor Type CCD
Number of Pixels (H x V) 640 x 480 1392 x 1040 2048 x 2048 3296 x 2472
Pixel Size 7.4 µm x 7.4 µm 6.45 µm x 6.45 µm 7.4 µm x 7.4 µm 5.5 µm x 5.5 µm
Optical Format 1/3" Format
(5.92 mm Diagonal)
2/3" Format
(11 mm Diagonal)
4/3" Format
(21.4 mm Diagonal)
4/3" Format
(22 mm Diagonal)
Peak Quantum Efficiency
(Click for Plot)
55% (at 500 nm) 10% (at 485 nm) Monochrome: 60% (at 500 nm)
Color: Click for Plot
Monochrome: 52% (at 500 nm)
Color: Click for Plot
Monochrome: 51% (at 460 nm)
Color: Click for Plot
Max Frame Rate
(Full Sensor)
200.7 fps (at 40 MHz
Dual-Tap Readout)
23 fps (at 40 MHz
Single-Tap Readout)
25.8 fps (at 40 MHz
Quad-Tap Readout)a
17.1 fps (at 40 MHz
Quad-Tap Readout)b
Read Noise <15 e- at 20 MHz <7 e- at 20 MHz (Standard Models)
<6 e- at 20 MHz (-TE Models)
<12 e- at 20 MHz <10 e- at 20 MHz
Digital Output (Max) 14 Bitc 14 Bit 14 Bitc
Available Fanless Cooling Passive Thermal Management -20 °C at 20 °C Ambient Temperature -10 °C at 20 °C Ambient
Available PC Interfaces USB 3.0, Gigabit Ethernet, or Camera Link
Housing Dimensions
(Click to Enlarge)
Non-Cooled Scientific CCD Camera Cooled Scientific CCD Camera
Non-Cooled Scientific CCD Camera
Typical Applications Ca++ Ion Imaging
Particle Tracking
Flow Cytometry
SEM/EBSD
UV Inspection
Fluorescence Microscopy
VIS/NIR Imaging
Quantum Dots
Multispectral Imaging
Immunohistochemistry (IHC)
Retinal Imaging
Fluorescence In Situ Hybridization (FISH)
Fluorescence Microscopy
Transmitted Light Micrsoscopy
Whole-Slide Microscopy
Electron Microscopy (TEM/SEM)
Inspection
Material Sciences
Large FOV Slide Imaging
Histopathology
Inspection
Multispectral Imaging
Immunohistochemistry (IHC)
  • Limited to 13 fps at 40 MHz dual-tap readout for Gigabit Ethernet cameras; quad-tap readout is unavailable for Gigabit Ethernet cameras.
  • Limited to 8.5 fps at 40 MHz dual-tap readout for Gigabit Ethernet cameras; quad-tap readout is unavailable for Gigabit Ethernet cameras.
  • Gigabit Ethernet cameras operating in dual-tap readout mode are limited to 12-bit digital output.

Scientific Camera Applications

Select a Topic


Multispectral Imaging

The video to the right is an example of a multispectral image acquisition using a liquid crystal tunable filter (LCTF) in front of a monochrome camera. With a sample slide exposed to broadband light, the LCTF passes narrow bands of light that are transmitted from the sample. The monochromatic images are captured using a monochrome scientific camera, resulting in a datacube – a stack of spectrally separated two-dimensional images which can be used for quantitative analysis, such as finding ratios or thresholds and spectral unmixing.

In the example shown, a mature capsella bursa-pastoris embryo, also known as Shepherd's-Purse, is rapidly scanned across the 420 nm - 730 nm wavelength range using Thorlabs' KURIOS-WB1 Liquid Crystal Tunable Filter. The images are captured using our 1501M-GE Scientific Camera, which is connected, with the liquid crystal filter, to a Cerna Series Microscope. The overall system magnification is 10X. The final stacked/recovered image is shown below.

Multispectral imaging
Click to Enlarge

Final Stacked/Recovered Image

 


Thrombosis Studies

Thrombosis is the formation of a blood clot within a blood vessel that will impede the flow of blood in the circulatory system. The videos below are from experimental studies on the large-vessel thrombosis in Mice performed by Dr. Brian Cooley at the Medical College of Wisconsin. Three lasers (532 nm, 594 nm, and 650 nm) were expanded and then focused on a microsurgical field of an exposed surgical site in an anesthenized mouse. A custom 1.4 Megapixel Camera with integrated filter wheel were attached to a Leica Microscope to capture the low-light fluorescence emitted from the surgical site. See the videos below with their associated descriptions for further infromation.

Arterial Thrombosis

In the video above, a gentle 30-second electrolytic injury is generated on the surface of a carotid artery in an atherogenic mouse (ApoE-null on a high-fat, “Western” diet), using a 100-micron-diameter iron wire (creating a free-radical injury). The site (arrowhead) and the vessel are imaged by time-lapse fluorescence-capture, low-light camera over 60 minutes (timer is shown in upper left corner – hours:minutes:seconds). Platelets were labeled with a green fluorophore (rhodamine 6G) and anti-fibrin antibodies with a red fluorophore (Alexa-647) and injected prior to electrolytic injury to identify the development of platelets and fibrin in the developing thrombus. Flow is from left to right; the artery is approximately 500 microns in diameter (bar at lower right, 350 microns).


Venous Thrombosis

In the video above, a gentle 30-second electrolytic injury is generated on the surface of a murine femoral vein, using a 100-micron-diameter iron wire (creating a free-radical injury). The site (arrowhead) and the vessel are imaged by time-lapse fluorescence-capture, low-light camera over 60 minutes (timer is shown in upper left corner – hours:minutes:seconds). Platelets were labeled with a green fluorophore (rhodamine 6G) and anti-fibrin antibodies with a red fluorophore (Alexa-647) and injected prior to electrolytic injury to identify the development of platelets and fibrin in the developing thrombus. Flow is from left to right; the vein is approximately 500 microns in diameter (bar at lower right, 350 microns).

Reference: Cooley BC. In vivo fluorescence imaging of large-vessel thrombosis in mice. Arterioscler Thromb Vasc Biol 31, 1351-1356, 2011. All animal studies were done under protocols approved by the Medical College of Wisconsin Institutional Animal Care and Use Committee.

 
  Contact TSI
Jason Mills
Jason Mills
General Manager,
Thorlabs Scientific Imaging

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OEM or Custom Cameras for Your Application

Thorlabs Scientific Imaging makes it easy to get the camera that you need for a specific application. Along with the large selection of standard scientific cameras, we also offer customized and OEM products. This includes high-performance cameras, board-level cameras, custom camera housings, or software. If you have special requirements, a custom application, or general questions about our capabilities, please contact us; we will work with you to get the product you need for your application.

Customizing a scientific camera can be done from scratch or by using one of our existing standard cameras as a starting point. TSI simplifies this process by using the two-step process below. Small changes made to our existing stock, such as private labeling, timing circuitry within the electronics, or mechanical changes, can be quickly and easily done using these steps. When designing a custom camera from scratch, we will help walk you through everything detailed below. The process is simplified to help you match the camera to the specific needs of your application. We also offer Kanban options for OEM customers.

 

Scientific Camera
Common Fluorophore Emission Wavelengths Overlaid with QE Curves for our 1.4 Megapixel Cameras

Step 1: Analyze your Custom or OEM Requirements

  • Imaging Specifications:
    • Sensitivity
    • Wavelength
    • Resolution
    • Speed
  • System Requirements:
    • Operating Environment
    • Space Constraints
    • Interfaces
    • Software
  • Application Space:
    • Compliance Issues
    • Future Developments
    • Logistics
Scientific Camera
Scientific Camera
Click to Enlarge

Custom Housing
Scientific Camera
Click to Enlarge

Custom Circuit Board

Step 2: Work with TSI to Configure a Solution

Software
Click to Enlarge

API/SDK for Software Developers
  • Imager Options:
    • UV, Visible, or NIR Spectrum
    • 1.4 Megapixel, 4 Megapixel, 8 Megapixel, or Fast Frame Rate CCD
    • sCMOS or CMOS
  • I/O Options:
    • USB 3.0
    • Camera Link
    • Gigabit Ethernet
  • Camera Body Options:
    • Standard Non-Cooled
    • Hermetically Sealed with Two-Stage TEC
    • Private Labeling
    • Electronics Modifications
    • Optics Mounting Options (C-Mount Threading is Standard)
  • Electronics Modifications
    • Customized Firmware
    • Application-Specific Timing and Triggering Modes
  • Software:
    • Initial Evaluation Using ThorCam™ GUI for Cameras: Region-of-Interest (ROI) and Binning Modes, Supports 32- and 64-Bit Windows® 7
    • Algorithm Development Using Popular Third-Party Support Such as MATLAB, µManager/ImageJ, LabVIEW, and Metamorph
    • API / SDK Provided for Software Developers and OEM Customers
  • Supply Chain:
    • Kanban Stocking Agreements

OEM Brochure

Our Expertise in the Photonics and Imaging Industry

Thorlabs is a leading photonics company that develops and manufactures a broad portfolio of technologies ranging from optical components to advanced imaging systems. We develop and manuafacture most of our components at our extensive high-tech fabrication facilities. The facilities include manufacturing capabilities for motion control products, optoelectronics, semiconductors, optical fiber, optomechanics, optics, and optical coatings. Components that directly support our scientific camera line are filters and filter wheels, objective and scan lenses, zoom lenses, telecentric lenses, mounting adapters, LEDs, microscopy components and stages, and rigid cage systems.

Competencies

  • Extensive Knowledge of Photonics Technology
  • Unique Skillset to Design and Manufacture Low-Noise, High-Performance Scientific Cameras, Interfaces, and Software
  • Vertically Integrated Manufacturing Facilities
  • Variety of Existing Products from Across Different Fields
  • Close Contact with Research Labs Around the World

Experienced Team

  • Interdisciplinary Teams Comprised of Scientists, Engineers, and Technicians
  • Extensive Portfolio of Products Developed and Manufactured by Thorlabs Ranging From Mechanical Components to Imaging Systems
  • Many Optical Systems Successfuly Designed, Manufactured, and Deployed into the Field
TSI Logo

A Message from TSI's General Manager

As a researcher and system designer, you are accustomed to solving difficult problems but may be frustrated by the inadequacy of the available instrumentation and tools. The product development team at Thorlabs Scientific Imaging is continually looking for new challenges to push the boundaries of Scientific Cameras using various sensor technologies. We welcome your input in order to leverage our team of senior research and development engineers to help meet your advanced imaging needs.

Thorlabs' purpose is to support advances in research and development through our product offerings. Your input will help us steer the direction of our scientific camera product line to support these advances. If you have a challenging application that requires a more advanced scientific camera than is currently available, I would be excited to hear from you.

We're All Ears!

Sincerely,
Jason Mills
Jason Mills
General Manager
Thorlabs Scientific Imaging


Posted Comments:
gstanford  (posted 2018-11-05 16:57:09.677)
Webteam testing. please ignore.
user  (posted 2018-04-26 20:29:13.343)
THIS IS A TEST
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