Fiber Optic Cannulae with Diffuser Tip, Ø200 µm Core

  • Diffuser Tip Scatters Output Light Over Wide Angle
  • 2, 5, 10, or 20 mm Fiber Length
  • Ø1.25 mm Ceramic Ferrule
  • Custom Versions Available


2 mm Cannula Fiber with Diffuser Tip


5 mm Cannula Fiber with Diffuser Tip


10 mm Cannula Fiber with Diffuser Tip


20 mm Cannula Fiber with Diffuser Tip

Cannula Without Diffuser Tip

Cannula With Diffuser Tip

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Cannula Fiber Specifications
Fiber Type FT200EMT
Wavelength Range
(Click for Plot)
400 - 2200 nm
Fiber Core Diameter 200 ± 5 µm
Fiber Outer Diameter 225 ± 5 μm
Numerical Aperture 0.39 (Without Diffuser Tip)
Transmission (Typical)a 95% @ 470 nm
Min/Max Output Powerb ≥50% Over 220° Range @ 470 nm
  • The transmission is specified as the total output power relative to the same cannula without a diffuser tip.
  • The ratio of the minimum output power to the maximum output power at any angle over the specified range.

Click to Enlarge
Comparison of CFMLC12L10 Standard Cannula with CFDSB10 Cannula with Diffuser Tip; the output powers are not normalized relative to each other. For normal cannula, the profile is wavelength independent; however, with the diffuser tip, there is increased scattering for shorter wavelengths.

Click to Enlarge
The diffuser tip scatters the ouput light.


  • Cannulae with Diffuser Tip that Scatters Output Light (>220° Angle)
  • Easier Excitation of Cells and Less Dependence on Fiber Orientation
  • Ø200 µm Core, 0.39 NA Fiber Secured in Ø1.25 mm (LC) Ceramic Ferrule
  • Custom Cannulae Available (Contact Tech Support with Inquiries)

Thorlabs' Diffusing Cannulae feature a tip made from a highly diffusing material that scatters the output light over a wide angle. The diffuser material provides a high scattering cross section over the entire operating wavelength range. This allows for simpler optical excitation of all cells near the implanted cannula and less dependence on the fiber orientation. Diffused cannulae can also be used in imaging applications.

These cannulae use a Ø200 µm, 0.39 NA fiber (Item # FT200EMT) secured within a Ø1.25 mm (LC) ceramic ferrule. The fiber ends are flat cleaved to a pre-determined length (2, 5, 10, or 20 mm). An implant guide for the cannulae sold on this page is also available below in packs of one or five; the 2 mm cannula cannot be used with an implant guide.

Ceramic LC ferrules are minimally invasive and lightweight, making them ideal for smaller specimens or placing multiple cannulae in close proximity. After implantation using stereotaxic guidance, the ferrule remains exposed; this provides an interface with our line of Optogenetics Equipment (see below for a diagram of a typical setup). 

Each cannula includes a protective cap that shields the ferrule end from dust and other hazards. Additional CAPL Fiber Caps are also sold separately. If the ferrule end becomes dirty from use, we offer a selection of inspection tools, as well as fiber optic cleaning products.

Cleaning and Handling
The cannula fiber can be gently wiped with a Kimwipe®† or CTA10 Cotton-Tipped Applicator and 70% ethanol or isopropyl alcohol. The cannula can also be cleaned using an ultrasonic cleaner while ensuring that the tip does not come into contact with any solid surface.

Kimwipes® is a registered trademark of the Kimberly-Clark Corporation.

Mating Sleeve and Patch Cable Compatibility
The ferrule diameter of a patch cable and cannula is the key factor for physical compatibility with an interconnect or mating sleeve. Mixing stainless steel and ceramic ferrules should not introduce significant additional signal losses. Cannulae and patch cables using Ø1.25 mm (LC) ferrules can be connected using the ADAL1 mating sleeve or ADAL3 interconnect.

Custom Cannulae and High-Volume Orders
Thorlabs also manufactures custom fiber optic cannulae. We can provide different scattering profiles, fiber and/or ferrule types, as well as different fiber lengths; please contact Tech Support for details. High-volume orders are also possible; please contact OEM Sales for more information. 

Optogenetics Product Family for In Vivo Applications

Thorlabs offers a wide variety of products designed to support in vivo optogenetics applications. Please visit the OG Selection Guide tab above to see a full listing of available products for different applications.

Optogenetics System Schematic

Related Optogenetics Products
Light Sources Patch Cables (Ø200 µm Core, 0.39 NA) Mating Cannulae (Ø200 µm Core, 0.39 NA) Accessories
Fiber-Coupled LEDs
MM Laser, 473 nm
Rotary Joint
Dual Core
Bifurcated Y-Cables
Mating Sleeves
Dual Core
Diffuser Tip
Implant Guides
Cannula Holders

Optogenetics Selection Guide

Thorlabs offers a wide range of optogenetics components; the compatibility of these products in select standard configurations is discussed in detail here. Please contact Technical Support for assistance with items outside the scope of this guide, including custom fiber components for optogenetics.


Single-Site Stimulation

One Light Source to One Cannula Implant

The most straightforward method for in vivo light stimulation of a specimen is to use a single fiber optic with a single LED light source. The single wavelength LED is powered by an LED driver, and then the illumination output is fiber-coupled into a patch cable, which connects to the implanted cannula. See the graphics and expandable compatibility tables below for the necessary patch cables and cannulae to create this setup. To choose the appropriate LED and driver, see below or the full web presentation.

Click on Each Component for More Information

LED DriverLED DriverFiber-Coupled LEDFiber-Coupled LEDSMA to Ferrule Patch Cable with Optional Rotary JointSMA to Ferrule Patch Cable with Optional Rotary JointADAF2 InterconnectADAF2 InterconnectFiber Optic CannulaFiber Optic Cannula


Bilateral Stimulation

The ability to accurately and simultaneously direct light to multiple locations within a specimen is desired for many types of optogenetics experiments. For example, bilateral stimulation techniques typically target neurons in two spatially separated regions in order to induce a desired behavior. In more complex experiments involving the simultaneous inhibition and stimulation of neurons, delivering light of two different monochromatic wavelengths within close proximity enables the user to perform these experiments without implanting multiple cannulae, which can increase stress on the specimen.

Bilateral stimulation can be achieved with several different configurations depending on the application requirements. The sections below illustrate examples of different configurations using Thorlabs' optogenetics products.

Option 1: One Light Source to Two Cannula Implants Using Rotary Joint Splitter

Thorlabs' RJ2 1x2 Rotary Joint Splitter is designed for optogenetics applications and is used to split light from a single input evenly between two outputs. The rotary joint interface allows connected patch cables to freely rotate, reducing the risk of fiber damage caused by a moving specimen. See the graphic and compatibility table below for the necessary cables and cannulae to create this setup. For LEDs and drivers, see below or the full web presentation.

LED DriverFiber-Coupled LEDHybrid Patch Cable1x2 Rotary Joint SplitterOG Patch CableOG Patch CableADAF2 InterconnectADAF2 InterconnectFiber Optic CannulaFiber Optic CannulaFiber Optic Cannula

Option 2: One or Two Light Sources to Two Cannula Implants

If the intent is for one LED source to connect to two cannulae for simultaneous light modulation, then a bifurcated fiber bundle can be used to split the light from the LED into each respective cannula. For dual wavelength stimulation (mixing two wavelengths in a single cannula) or a more controlled split ratio between cannula, one can use a multimode coupler to connect one or two LEDs to the cannulae. If one cable end is left unused, the spare coupler cable end may be terminated by a light trap. See the graphic and compatibility table below for the necessary cables and cannulae to create this setup. For LEDs and drivers, see below or the full web presentation.

Click on Each Component Below for More Information

LED DriverLED DriverFiber-Coupled LEDFiber-Coupled LEDPatch CabletextY-CableMating SleeveMating SleeveMating SleeveMating SleeveFiber Optic CannulaFiber Optic CannulaFiber Optic CannulaFiber Optic Cannula

LED Driver2nd LED DriverLED Driver textFiber-Coupled LED2nd Fiber-Coupled LEDFiber-Coupled LED textMultimode CouplerMultimode Coupler TextADAF2 InterconnectADAF2 Interconnect TextADAF2 InterconnectADAF2 Interconnect TextFiber Optic CannulaFiber Optic CannulaFiber Optic CannulaFiber Optic Cannula


Two Light Sources into One Dual-Core Cannula Implant

For bilateral stimulation applications where the two cannulas need to be placed in close proximity (within ~1 mm), Thorlabs offers dual-core patch cables and cannulae that are designed for this specific application. Each core is driven by a separate light source, enabling users to stimulate and/or supress nerve cells in the same region of the specimen. See the graphic and compatibility table below for the necessary cables and cannulae to create this setup. For LEDs and drivers, see below or the full web presentation.

LED Driver2nd LED DriverLED Driver TextFiber-Coupled LED2nd Fiber-Coupled LEDFiber-Coupled LEDsDual-Core Patch CableDual-Core Patch CableADAF2 InterconnectADAF2 InterconnectFiber Optic CannulaFiber Optic Cannula

Click on Each Component for More Information

Part Selection Table (Click Links for Item Description Popup)
Common Fiber Properties
Core Diameter 200 µm
Wavelength Range 400 - 2200 nm
NA 0.39
Fiber Type FT200EMT
Ferrule Stylea FC (Ø2.5 mm)
Dual-Core Patch Cable FC/PC Input BFY32FL1
SMA905 Input BFY32SL1
Compatible Mating Sleeve/Interconnect ADAF1
Dual-Core Fiber Optic Cannulaec Stainless Steel CFM32L10
  • FC components have a Ø2.5 mm ferrule end.
  • Patch cables for dual light source to single implant applications are highlighted in green above. Choose a patch cable with an input that matches your light source.
  • Available cannulae are highlighted in orange of the table above. Cannule within the same column are interchangeable.


LED Item # Wavelengtha Typical Opsin Output Powerb Color
M385F1c 385 nm EBFP, moxBFP 10.7 mW UV
M405F1c 405 nm mmilCFP, hcriGFP 3.7 mW UV
M430F1 430 nm ChR2 7.5 mW Violet
M455F3 455 nm ChIEF, bPAC 24.5 mW Royal Blue
M470F3 470 nm ChR2, ChR2-SFO 21.8 mW Blue
M490F3 490 nm Rh-CT, ChR2 (E123A) 3.1 mW Blue
M505F3 505 nm ChRGR, Opto-α1AR, Opto-β2AR 11.7 mW Cyan
M530F2 530 nm C1V1, VChR1 9.6 mW Green
M565F3 565 nm Arch, VChR1-SFO 13.5 mW Lime
M595F2 595 nm ChR2-SFO, eNpHR3.0 11.5 mW Amber
M625F2 625 nm ReChR 17.5 mW Red
  • Click the link for a spectrum and raw data.
  • Typical output power measured with a Ø400 µm Core, 0.39 NA multimode fiber.
  • Precautions must be taken to prevent looking directly at the UV light and UV light protective glasses must be worn to avoid eye damage. Exposure of the skin and other body parts to UV light should be avoided.


Fiber-Coupled LEDs and Drivers

Our fiber-coupled LEDs are ideal light sources for optogenetics applications. They feature a variety of wavelength choices and a convenient interconnection to optogenetics patch cables. Thorlabs offers fiber-coupled LEDs with nominal wavelengths ranging from 280 nm to 1050 nm. See the table to the right for the LEDs with the most popular wavelengths for optogenetics. A table of compatible LED drivers can be viewed by clicking below.

Posted Comments:
D Lepage  (posted 2022-04-07 18:53:17.68)
Hi, Would it be possible to know what material is used for the diffuser ? Also, what is the diffuser length ? Regards,
jgreschler  (posted 2022-04-15 11:19:01.0)
Thank you for reaching out to Thorlabs. You can request additional information and specifications on our products by reaching out to Unfortunately in this case both the pieces of information are proprietary.
Alejandro Gimeno  (posted 2021-09-24 10:14:42.4)
Greetings, I am interested in a diffuser with the purpose of breaking the coherence of the light coming from a laser. Is there some feedback or results about the level of coherence when this fiber diffuser is used?
azandani  (posted 2021-09-27 02:56:46.0)
Hello Alejandro, thank you for contacting Thorlabs. Unfortunately, we do not have any results for this as this product is primarily for increasing the divergence of the input light by scattering it over a large angle ( >220 degrees). We will contact you to discuss this further.
jcogger  (posted 2018-02-22 20:54:56.907)
I am interested in buying the diffuser tips as shown on the CFDSB02. Can you explain how the diffuser works? Thanks
llamb  (posted 2018-03-08 02:44:02.0)
Hello, thank you for contacting Thorlabs. The diffuser tip is integrated into the end of the fiber so that when the output light enters the high scattering cross-section, a wider output angle is achieved compared to the standard fiber material. I will reach out to you directly as well.

Ø1.25 mm (LC) Cannulae with Diffuser Tip

Based on your currency / country selection, your order will ship from Newton, New Jersey  
+1 Qty Docs Part Number - Universal Price Available
CFDSB02 Support Documentation
CFDSB02Fiber Optic Cannula with Diffuser Tip, Ø1.25 mm Ceramic Ferrule, Ø200 µm Core, 0.39 NA, L=2 mm
CFDSB05 Support Documentation
CFDSB05Fiber Optic Cannula with Diffuser Tip, Ø1.25 mm Ceramic Ferrule, Ø200 µm Core, 0.39 NA, L=5 mm
CFDSB10 Support Documentation
CFDSB10Fiber Optic Cannula with Diffuser Tip, Ø1.25 mm Ceramic Ferrule, Ø200 µm Core, 0.39 NA, L=10 mm
CFDSB20 Support Documentation
CFDSB20Fiber Optic Cannula with Diffuser Tip, Ø1.25 mm Ceramic Ferrule, Ø200 µm Core, 0.39 NA, L=20 mm

Cannula Implant Guide

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Cross Section Drawing of OGL with CFML22L05 Cannula (Not Included)

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Implant Guide Assembly
  • Improves Adhesion and Stability During Implantation
  • Compatible with Ø1.25 mm Fiber Optic Cannulae with ≥5 mm Length
  • Ø3.8 mm Mounting Surface with Grooved Ring for Dental Cement
  • Lightweight Surgical Titanium Construction (0.09 g)
  • Weep Holes for Glue and Epoxy to Secure a Cannula
  • Compatible with Stereotaxic Cannula Holders

This Cannula Implant Guide is designed to provide guidance and stability for a fiber optic cannula during an implantation procedure. The bottom surface of each implant guide features a roughened surface and circular groove that increases the surface area available to dental cement and improves adhesion to the specimen. A 1.6 mm long protrusion on the implant guide helps stabilize the guide when implanted. The implant is constructed using lightweight surgical titanium (0.09 g) which can be sterilized prior to use. The OGL implant guide is compatible with our standard Ø1.25 mm cannulae (ceramic and stainless steel). When assembled, the length of the protruding fiber is reduced by 1 mm; therefore, the implant guide cannot be used with our 2 mm long cannulae. For convenience, the guide is offered in packs of one or five.

For best results when implanting a cannula, the OGL should be used with a cannula holder and stereotaxic guidance equipment. To affix the cannula within the implant guide, first insert the cannula into the receptacle of the implant guide (see drawing to the right). Then, add a small amount of cement or epoxy to the cannula via the two Ø0.8 mm weep holes. Finally, attach the cannula ferrule to an XCL cannula holder.

Based on your currency / country selection, your order will ship from Newton, New Jersey  
+1 Qty Docs Part Number - Universal Price Available
OGL Support Documentation
OGLImplant Guide for Ø1.25 mm Cannula
OGL-5 Support Documentation
OGL-5Implant Guide for Ø1.25 mm Cannula, Pack of 5