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Ventilated Mouse Lung
The mouse lung images shown below were acquired using a Thorlabs Spectral Radar OCT system with a center wavelength of 930 nm. In general, the Spectral Radar OCT system has a penetration depth of 1 to 2 mm, and an axial resolution of ~10 µm. In these experiments, the imaging depth was 1.6mm with a resolution of 6 µm. Perfundated and ventilated lungs were examined during inspiration and expiration, while the change of volume and shape of alveolar areas was visualized (see Fig. 1a and 1b). The mismatch of the index of refraction between tissue and air-filled structures makes imaging extremely difficult. By filling the lung with an index-matching fluid, imaging down to a depth of 1 mm was possible.
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| Figure 1: Morphological changes in a ventilated mouse lung. |
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These experiments were performed to study the relation between mechanical stress and inflammation, which is important for artificially ventilated patients. The stresses that occur in single alveoli during ventilation are still poorly defined. Based on 3D OCT imaging, it is possible to get detailed structural and spatial information of subpleural contiguous regions of lungs at different alveolar pressure in order to develop appropriate theoretical models of the mechanics of real lung structures under mechanical ventilation.
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| Figure 2: A sequence of 9 B-scans of the mouse lung prefilled with index-matching fluid at pressure equivalent to 3 cm water-ventilation pressure covering a total length of 0.2 mm. Longitudinal resolution in air is 6 µm. The 3D reconstruction of sub-pleural area is also shown in the figure. |
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Image courtesy: Prof. Stefan Uhlig, Dag Friedrichs, Dr. Eva Lankenau and Dr. Gereon Hüttmann, Lübeck, Germany.
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