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Functional Imaging
In January 2006, Thorlabs swept source OCT microscope (SS-OCM) system was used for rat brain imaging in Massachusetts General Hospital, to study the functional activation in the rat somatosensory cortex. The SS-OCM system is modified to provide simultaneous microscope viewing of the sample using a high sensitivity CCD camera and cross-sectional imaging using the Thorlabs OCT engine. These two imaging channels were synchronized to provide image data that was co-registered for post image processing. Preliminary results suggest that functional activation in the rat somatosensory cortex can be monitored through the analysis of OCT images.
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| Figure 1. Thorlabs swept source OCT system adapted to rat brain functional imaging experiment. |
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This study is a collaborative research project between Massachusetts Institute of Technology (MIT) and Massachusetts General Hospital (MGH), under the direction of Prof. James Fujimoto and Prof. David Boas. The objective of this research is to develop a new optical imaging tool for better understanding the complex neurovascular coupling relationship, through the study of the spatiotemporal characteristics of the hemodynamic and functional activation of animal somatosensory cortex. Details about this research work were previously published in Optics Letters , 31 (23), 2006.
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| Figure 2 (a): Registration of OCT images in the region of functional activation. The OCT scan was directed in the region of interest measured with video microscopy. (b):3D en-face functional OCT imaging of the rat brain. The red arrow represents the direction of the OCT scans, while the blue pixels show the location of the brain that is functionally activated after stimulation of the rat forepaw. (c): Cross-section of the rat brain with functional image data shows the skull (S), surface vasculature (V), and meningeal layers, including the dura mater (D).
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A movie showing the En-face OCT sectioning of the sample is shown in Figure 3.
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| Figure 3. En-face OCT sectioning of the mouse brain |
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Image & Movie Courtesy: Prof. James G. Fujimoto of Department of Electrical Engineering and Computer Science of Massachusetts Institute of Technology and Prof. David Boas of Massachusetts General Hospital and Harvard Medical School. We gratefully appreciate Aaron D. Aguirre and Yu Chen for leading the experiment.
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| Product Links |
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| Swept Source OCT Microscope System |
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| Spectral Radar OCT Imaging System |
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| Rapidly Swept Tunable Laser |
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